997b6c3cc697fa995754f23b3aae4829 TFG_Rafaela_definitivo.pdf 1ab81e152b3b0db036683e98fea57b89c19734f3 TFG_Rafaela_definitivo.pdf 8eca42d3dca5a783c299f10cda304ee86e74d698c5658986527af40ce69c813b TFG_Rafaela_definitivo.pdf Author: Rafaela Muñoz Alfaro Creator: Microsoft® Word 2016 Producer: www.ilovepdf.com CreationDate: Tue May 17 10:42:29 2022 CEST ModDate: Tue May 17 10:42:29 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 68 Encrypted: no Page size: 595.2 x 841.92 pts (A4) Page rot: 0 File size: 3188673 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Arial TrueType WinAnsi no no no 82 0 Times New Roman TrueType WinAnsi no no no 85 0 Times New Roman CID TrueType Identity-H yes no yes 88 0 ABCDEE+Calibri Light TrueType WinAnsi yes yes no 142 0 ABCDEE+Calibri,BoldItalic TrueType WinAnsi yes yes no 146 0 ABCDEE+Calibri TrueType WinAnsi yes yes no 150 0 ABCDEE+Calibri,Bold TrueType WinAnsi yes yes no 154 0 ABCDEE+Calibri,Bold CID TrueType Identity-H yes yes yes 328 0 Times New Roman,Bold TrueType WinAnsi no no no 1177 0 Times New Roman,Italic TrueType WinAnsi no no no 1180 0 Times New Roman,Bold CID TrueType Identity-H yes no yes 1183 0 Times New Roman,Italic CID TrueType Identity-H yes no yes 1191 0 Times New Roman,BoldItalic TrueType WinAnsi no no no 1199 0 Arial,Bold TrueType WinAnsi no no no 1356 0 Helvetica TrueType WinAnsi no no no 1417 0 ABCDEE+Courier New TrueType WinAnsi yes yes no 1678 0 ABCDEE+Calibri Light CID TrueType Identity-H yes yes yes 1711 0 ABCDEE+Times TrueType WinAnsi yes yes no 1731 0 ABCDEE+Wingdings CID TrueType Identity-H yes yes yes 1808 0 ABCDEE+Calibri CID TrueType Identity-H yes yes yes 2064 0 ABCDEE+Calibri Light,Italic TrueType WinAnsi yes yes no 4050 0 ABCDEE+Calibri Light,Italic CID TrueType Identity-H yes yes yes 4072 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-31 02:18:10 CEST RepresentationInformation: TFG_Rafaela_definitivo.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-10-24 10:42:31 CEST Size: 3188673 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 4190 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: LISTA DE FIGURAS Destination: 1 Item: Title: ABREVIATURAS Destination: 1 Item: Title: ABSTRACT Destination: 1 Item: Title: RESUM Destination: 1 Item: Title: RESUMEN Destination: 1 Item: Title: 1. INTRODUCCIÓN Destination: 1 Children: Item: Title: 1.2. CÁNCER DE MAMA Destination: 1 Children: Item: Title: 1.2.1. SUBTIPO TRIPLE NEGATIVO Destination: 1 Item: Title: 1.1. VESíCULAS EXTRACELULARES (VEs) Destination: 1 Children: Item: Title: 1.1.1. EXOSOMAS Destination: 1 Item: Title: 1.1.2. INTEGRINAS Destination: 1 Item: Title: 1.1.3. PROTEOGLICANO HEPARAN SULFATO Destination: 1 Item: Title: 2. HIPÓTESIS INICIAL Destination: 1 Item: Title: 3. OBJETIVOS Destination: 1 Item: Title: 4. MATERIAL Y MÉTODOS Destination: 1 Children: Item: Title: 5.1. CULTIVO CELULAR Destination: 1 Children: Item: Title: 4.1.1. LÍNEA CELULAR Destination: 1 Item: Title: 4.1.2. CONDICIONES DEL CULTIVO CELULAR Destination: 1 Item: Title: 4.1.3. DISOCIACIÓN CELULAR Destination: 1 Item: Title: 4.1.4. CONTEO CELULAR Destination: 1 Item: Title: 5.2. OBTENCIÓN DE EXOSOMAS Destination: 1 Children: Item: Title: 5.2.1. AISLAMIENTO DE EXOSOMAS Destination: 1 Item: Title: 5.2.2. CUANTIFICACIÓN DE EXOSOMAS Destination: 1 Item: Title: 5.2.3. TINCIÓN DE EXOSOMAS Destination: 1 Item: Title: 5.3. ENSAYOS IN VITRO Destination: 1 Children: Item: Title: 5.3.1. SIARN SDC1 Y SDC4 Destination: 1 Item: Title: 5.3.2. ENSAYO DE CAPTACIÓN DE EXOSOMAS Destination: 1 Item: Title: 5.3.3. ENSAYO DE FORMACIÓN DE COLONIAS Destination: 1 Item: Title: 5.3.4. ANÁLISIS ESTADíSTICOS Destination: 1 Item: Title: 6. RESULTADOS Y DISCUSIÓN Destination: 1 Children: Item: Title: 6.1. RESULTADOS PREELIMINARES DEL GRUPO Destination: 1 Item: Title: 6.2. RESULTADOS Destination: 1 Children: Item: Title: 6.2.1. ENSAYO CAPTACIÓN DE EVS EN SIARN DE SDC1 Y DE SDC4 Destination: 1 Item: Title: 6.2.2. NT4-BIOTINA Destination: 1 Item: Title: 7. CONCLUSIONES Destination: 1 Item: Title: 8. AT A GLANCE Destination: 1 Item: Title: 9. BIBLIOGRAFíA Destination: 1 Item: Title: 10. ANEXO PROTOCOLOS Destination: 1 Children: Item: Title: MATERIALES DE USO GENERAL: Destination: 1 Item: Title: REACTIVOS DE USO GENERAL: Destination: 1 Item: Title: FÁRMACOS Destination: 1 Item: Title: 1. SIARN SDC1 Y SDC4 Destination: 1 Item: Title: 2. CAPTACIÓN DE SIRNA SDC1 Y SDC4 – UPTAKE SIRNA SDC1 Y SDC4 Destination: 1 Children: Item: Title: 1.1. MATERIALES: Destination: 1 Item: Title: 1.2. PROCEDIMIENTO: Destination: 1 Item: Title: 3. CITOMETRÍA DE FLUJO Destination: 1 Children: Item: Title: 3.1. ANÁLISIS DE DATOS Destination: 1 Item: Title: 4. AISLAMENTO EXOSOMAS Destination: 1 Item: Title: 5. NT4-BIOTIN: EVS UPTAKE Destination: 1 Children: Item: Title: 5.1. MATERIALES: Destination: 1 Item: Title: 5.2. PROCEDIMIENTO Destination: 1 Item: Title: 6. NT4-BIOTIN: COLONOGENIC Destination: 1 Children: Item: Title: 6.1. PROCEDIMIENTO Destination: 1 Item: Title: 7. NT4-BIOTIN: TOXICITY Destination: 1 Item: Title: 8. TINCIÓN DE EXOSOMAS Destination: 1 Item: Title: 9. DISOCIACIÓN CELULAR Destination: 1 Item: Title: 11. ANEXO TABLAS Destination: 1 Children: Item: Title: A. CLASIFICACIÓN IHQ DEL CÁNCER DE MAMA Destination: 1 Item: Title: b. SUBTIPOS DE TNBC Destination: 1 Item: Title: C. TIPOS DE HSPG Destination: 1 Item: Title: D. QRT-PCR Destination: 1 Item: Title: E. CMF- UPTAKE SIRNA DE SDC1 Y SDC4 Destination: 1 Item: Title: F. RESULTADOS NUMERICOS DE UPTAKE SIRNA DE SDC1 Y SDC4 Destination: 1 Item: Title: G. NT4 VS. NT4-BIOTINA Destination: 1 Item: Title: H. CMF- UPTAKE NT4-BIOTINA A DOSIS ALTAS Destination: 1 Item: Title: I. RESULTADOS NUMÉRICOS DE UPTAKE NT4-BIOTIN A DOSIS MÁS ALTAS Destination: 1 Item: Title: J. RESULTADOS DEL ESPECTROFOTÓMETRO Destination: 1 Item: Title: K. RESULTADOS RELATIVOS AL CONTROL DEL ESPECTROFOTÓMETRO Destination: 1 Item: Title: 12. ANEXO FIGURAS SUPLEMENTARIAS Destination: 1 Children: Item: Title: 1. MEDICINA PERSONALIZADA Destination: 1 Item: Title: 2. REPRESENTACIÓN DE LA ESTRUCTURA DE los HSPGs Destination: 1 Item: Title: 3. ACTIVIDADES BIOLÓGICAS MODULADAS POR LA INTERACCIÓN DE HEPARAN SULFATO CON PROTEÍNAS Destination: 1 Item: Title: 4. CASCADA METASTÁSICA Y COMUNICACIÓN INTERCELULAR A NIVEL DE HSPG, ITGB3 Y EXOSOMAS Destination: 1 Item: Title: 5. RESULTADOS QRT-PCR Destination: 1 Item: Title: 6. ENSAYO DE CAPTACIÓN DE EVS DE SIRNA SDC1/SDC4 Destination: 1 Item: Title: 7. GRÁFICA DE LOS RESULTADOS DE UPTAKE SIRNA DE SDC1 Y SDC4 Destination: 1 Item: Title: 8. COMPARACIÓN ENTRE NT4-BIOTINA Y NT4 Destination: 1 Item: Title: 9. CMF DE LA CAPTACIÓN DE EXOSOMAS EN CÉLULAS TRATADAS CON NT4-BIOTINA Destination: 1 Item: Title: 10. ADAPTACIÓN DE LA CLASIFICACIÓN DE TUMORES DE MAMA DE LA OMS Destination: 1 Item: Title: 11. 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Flags: Print Destination: 1 Page: Sequence: 7 Page: Sequence: 8 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Page: Sequence: 12 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Page: Sequence: 20 Page: Sequence: 21 Page: Sequence: 22 Page: Sequence: 23 Page: Sequence: 24 Page: Sequence: 25 Page: Sequence: 26 Page: Sequence: 27 Page: Sequence: 28 Page: Sequence: 29 Page: Sequence: 30 Page: Sequence: 31 Page: Sequence: 32 Page: Sequence: 33 Page: Sequence: 34 Page: Sequence: 35 Page: Sequence: 36 Page: Sequence: 37 Page: Sequence: 38 Page: Sequence: 39 Page: Sequence: 40 Page: Sequence: 41 Page: Sequence: 42 Page: Sequence: 43 Page: Sequence: 44 Page: Sequence: 45 Page: Sequence: 46 Page: Sequence: 47 Page: Sequence: 48 Page: Sequence: 49 Page: Sequence: 50 Page: Sequence: 51 Page: Sequence: 52 Page: Sequence: 53 Page: Sequence: 54 Page: Sequence: 55 Page: Sequence: 56 Page: Sequence: 57 Page: Sequence: 58 Page: Sequence: 59 Page: Sequence: 60 Page: Sequence: 61 Page: Sequence: 62 Page: Sequence: 63 Page: Sequence: 64 Page: Sequence: 65 Page: Sequence: 66 Page: Sequence: 67 Page: Sequence: 68 Checksum: 1e78b720 Type: CRC32 Checksum: 997b6c3cc697fa995754f23b3aae4829 Type: MD5 Checksum: 1ab81e152b3b0db036683e98fea57b89c19734f3 Type: SHA-1