Pandemic and post-pandemic Influenza A (H1N1) infection in critically ill patients
Martin-Loeches, Ignacio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Díaz Santos, Emilio (Hospital Universitari Joan XXIII de Tarragona)
Vidaur, Loreto (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Torres, Antoni (Universitat de Barcelona)
Laborda, César (Hospital Universitari Vall d'Hebron)
Granada, Rosa (Hospital Universitari de Bellvitge)
Bonastre Mora, Juan (Hospital Universitari i Politècnic La Fe (València))
Martín, Mar (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Insausti, Josu (Complejo Hospitalario de Navarra)
Arenzana, Ángel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Guerrero, José Eugenio (Hospital General Universitario Gregorio Marañón)
Navarrete, Inés (Hospital Universitario Virgen de las Nieves (Granada))
Bermejo-Martin, Jesús F.. (Hospital Clínico Universitario de Valladolid)
Suárez, David (Universitat Autònoma de Barcelona)
Rodríguez, Alejandro (Hospital Universitari Joan XXIII de Tarragona)
H1N1 SEMICYUC/REIPI/CIBERES Working group

Fecha:	2011
Resumen:	Background: There is a vast amount of information published regarding the impact of 2009 pandemic Influenza A (pH1N1) virus infection. However, a comparison of risk factors and outcome during the 2010-2011 post-pandemic period has not been described. Methods: A prospective, observational, multi-center study was carried out to evaluate the clinical characteristics and demographics of patients with positive RT-PCR for H1N1 admitted to 148 Spanish intensive care units (ICUs). Data were obtained from the 2009 pandemic and compared to the 2010-2011 post-pandemic period. Results: Nine hundred and ninety-seven patients with confirmed An/H1N1 infection were included. Six hundred and forty-eight patients affected by 2009 (pH1N1) virus infection and 349 patients affected by the post-pandemic Influenza (H1N1)v infection period were analyzed. Patients during the post-pandemic period were older, had more chronic comorbid conditions and presented with higher severity scores (Acute Physiology And Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA)) on ICU admission. Patients from the post-pandemic Influenza (H1N1)v infection period received empiric antiviral treatment less frequently and with delayed administration. Mortality was significantly higher in the post-pandemic period. Multivariate analysis confirmed that haematological disease, invasive mechanical ventilation and continuous renal replacement therapy were factors independently associated with worse outcome in the two periods. HIV was the only new variable independently associated with higher ICU mortality during the post-pandemic Influenza (H1N1)v infection period. Conclusion: Patients from the post-pandemic Influenza (H1N1)v infection period had an unexpectedly higher mortality rate and showed a trend towards affecting a more vulnerable population, in keeping with more typical seasonal viral infection.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; Versió publicada
Publicado en:	Critical Care, Vol. 15, N. R286 (November 2011) , p. 1-11, ISSN 1466-609X

DOI: 10.1186/cc10573
PMID: 22126648

11 p, 422.4 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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