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Protective coatings for intraocular wirelessly controlled microrobots for implantation : corrosion, cell culture, and in vivo animal tests
Pokki Juho (ETH Zürich. Institute of Robotics & Intelligent Systems)
Ergeneman Olgaç (ETH Zürich. Institute of Robotics & Intelligent Systems)
Chatzipirpiridis, George (ETH Zürich. Institute of Robotics & Intelligent Systems)
Lühmann, Tessa (University of Würzburg. Institute for Pharmacy and Food Chemistry)
Sort Viñas, Jordi (Universitat Autònoma de Barcelona. Departament de Física)
Pellicer, Eva Maria (Universitat Autònoma de Barcelona. Departament de Física)
Pot, Simon A (University of Zurich. Vetsuisse Faculty)
Spiess, Bernhard M. (University of Zurich. Vetsuisse Faculty)
Pané, Salvador (ETH Zürich. Institute of Robotics & Intelligent Systems)
Nelson, Bradley J. (ETH Zürich. Institute of Robotics & Intelligent Systems)

Data: 2016
Resum: Diseases in the ocular posterior segment are a leading cause of blindness. The surgical skills required to treat them are at the limits of human manipulation ability, and involve the risk of permanent retinal damage. Instrument tethering and design limit accessibility within the eye. Wireless microrobots suturelessly injected into the posterior segment, steered using magnetic manipulation, are proposed for procedures involving implantation. Biocompatibility is a prerequisite for these procedures. This paper investigates the use of cobalt-nickel microrobots coated with polypyrrole, and gold, which has been used as an ocular implant material. Polypyrrole has well-established biocompatibility properties, but no reports concerning its ocular implantation is available. Coated and uncoated microrobots were investigated for their corrosion properties, and solutions that had contained coated and uncoated microrobots for one week were tested for cytotoxicity by monitoring NIH3T3 cell viability. None of the microrobots showed significant corrosion currents and corrosion potentials were as expected in relation to the intrinsic nobility of the materials. NIH3T3 cell viability was not affected by the release medium, in which coated/uncoated microrobots were stored. In vivo tests inside rabbit eyes were performed using coated microrobots. There were no significant inflammatory responses during the first week after injection. An inflammatory response detected after two weeks was likely due to a lack of longer-duration biocompatibility. The results provide valuable information for those who work on implant technology and biocompatibility. Coated microrobots have the potential to facilitate a new generation of surgical treatments, diagnostics and drug-delivery techniques, when implantation in the ocular posterior segment will be possible.
Nota: Grup: Gnm3 Funding
Nota: Número d'acord de subvenció EC/FP7/268004
Nota: Número d'acord de subvenció MINECO/RYC-2012/10839
Nota: Número d'acord de subvenció AGAUR/2015/SGR-1015
Drets: Tots els drets reservats
Llengua: Anglès
Document: article ; recerca ; acceptedVersion
Matèria: Ophthalmic microrobots ; Biocompatibility ; Corrosion ; Cell culture ; Rabbit model
Publicat a: Journal of Biomedical Materials Research Part B, Vol 104, Issue 1 (January 2016) , ISSN 1552-4981

DOI: 10.1002/jbm.b.33618

20 p, 3.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Grup de nanoenginyeria de materials, nanomagnetisme i nanomecànica (Gnm3)
Articles > Articles de recerca
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 Registre creat el 2016-02-03, darrera modificació el 2017-10-14

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