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Delineating the factors and cellular mechanisms involved in the survival of cerebellar granule neurons.
Xifro Collsamata, Francesc Xavier (Universitat de Girona. Departament de Ciències Mèdiques)
Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Institut de Neurociències)

Data: 2015
Resum: Cerebellar granule neurons (CGNs) constitute the most abundant neuronal population in the mammalian brain. Their postnatal generation and the feasibility to induce their apoptotic death in vitro make them an excellent model to study the effect of several neurotransmitters and neurotrophins. Here, we first review which factors are involved in the generation and proliferation of CGNs in the external granule layer (EGL) and in the regulation of their differentiation and migration to internal granule layer (IGL). Special attention was given to the role of several neurotrophins and the NMDA subtype of glutamate receptor. Then, using the paradigm of potassium deprivation in cultured CGNs, we address several extracellular factors that promote the survival of CGNs, with particular emphasis on the cellular mechanisms. The role of specific protein kinases leading to the regulation of transcription factors and recent data involving the small G protein family is also discussed. Finally, the participation of some members of Bcl-2 family and the inhibition of mitochondria-related apoptotic pathway is also considered. Altogether, these studies evidence that CGNs are a key model to understand the development and the survival of neuronal populations.
Nota: Número d'acord de subvenció MICINN/SAF2011-30281
Nota: Número d'acord de subvenció CIBERNED/CB06/05/0042
Nota: Número d'acord de subvenció AGAUR/SGR2009-1231
Nota: Número d'acord de subvenció AGAUR/SGR2014-0984
Drets: Tots els drets reservats.
Llengua: Anglès.
Document: article ; article de revisió ; acceptedVersion
Matèria: Cerebellar granule neurons ; Development ; Differentiation ; Neuroprotection ; Survival pathways
Publicat a: Cerebellum, Vol. 14, Num. 3 (June 2015) , ISSN 1473-4222

DOI: 10.1007/s12311-015-0646-z

12 p, 211.7 KB

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