Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens
López Hernández, Yamilé (Universidad Autónoma de San Luis Potosí. Centro de Biociencias)
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Pinos-Rodríguez, Juan M. (Universidad Autónoma de San Luis Potosí. Centro de Biociencias)
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Data:	2015
Resum:	Biological disease models can be difficult and costly to develop and use on a routine basis. Particularly, in vivo lung infection models performed to study lung pathologies use to be laborious, demand a great time and commonly are associated with ethical issues. When infections in experimental animals are used, they need to be refined, defined, and validated for their intended purpose. Therefore, alternative and easy to handle models of experimental infections are still needed to test the virulence of bacterial lung pathogens. Because non-mammalian models have less ethical and cost constraints as a subjects for experimentation, in some cases would be appropriated to include these models as valuable tools to explore host-pathogen interactions. Numerous scientific data have been argued to the more extensive use of several kinds of alternative models, such as, the vertebrate zebrafish (Danio rerio), and non-vertebrate insects and nematodes (e. g. , Caenorhabditis elegans) in the study of diverse infectious agents that affect humans. Here, we review the use of these vertebrate and non-vertebrate models in the study of bacterial agents, which are considered the principal causes of lung injury. Curiously none of these animals have a respiratory system as in air-breathing vertebrates, where respiration takes place in lungs. Despite this fact, with the present review we sought to provide elements in favor of the use of these alternative animal models of infection to reveal the molecular signatures of host-pathogen interactions.
Ajuts:	Ministerio de Ciencia e Innovación BFU2010-17199 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1280
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	C. elegans ; Drosophila melanogaster ; Galleria mellonella ; Alternative model ; Cystic fibrosis ; Pneumonia ; Tuberculosis ; Zebrafish
Publicat a:	Frontiers in microbiology, 2015 , ISSN 1664-302X

DOI: 10.3389/fmicb.2015.00038
PMID: 25699030

19 p, 1.1 MB

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