Taxane-Induced Peripheral Neurotoxicity

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(Universitat Autònoma de Barcelona. Institut de Neurociències)

Data:	2015
Resum:	Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Taxane ; Paclitaxel ; Docetaxel ; Nab-paclitaxel ; Cabazitaxel ; Chemotherapy-induced peripheral neuropathy ; Neurotoxicity ; Peripheral neuropathy ; Taxane-induced peripheral neuropathy
Publicat a:	Toxics, Vol. 3 Núm. 2 (April 2015) , p. 152-169, ISSN 2305-6304

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Registre creat el 2016-12-09, darrera modificació el 2022-03-26