Long-Term Mortality of Patients with an Alcohol-Related Wernicke-Korsakoff Syndrome
Sanvisens, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zuluaga Cruz, Andrea Paola (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rivas, Inmaculada (Centre Delta)
Tor Aguilera, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Marcos, Miguel (Hospital Universitario de Salamanca)
Chamorro, Antonio J. (Hospital Universitario de Salamanca)
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Data:	2017
Resum:	Aims: To characterize a series of contemporary patients with alcohol-related Wernicke's encephalopathy (WE) or Korsakoff's syndrome (KS) and to update the current prognosis of disease. Methods: Retrospective and prospective study of patients diagnosed with an alcohol-related WE or KS between 2002 and 2011 in a tertiary hospital. Socio-demographic, alcohol use characteristics, signs and symptoms, co-morbidity and blood parameters were obtained at admission. Patients were followed up until 2013 and causes of death were ascertained through the review of charts. Results: Sixty-one patients were included (51 with WE and 10 with KS). Among patients with WE, 78% were men and age at diagnosis was 57 years (interquartile range (IQR): 49-66). Twenty-three percent fulfilled the classic WE triad. Regarding Caine's criteria for WE, 70. 6% presented with at least two out of four signs or symptoms. Median follow-up of patients with WE syndrome was 5. 3 years (IQR: 2. 6-8. 8), the cumulated mortality was 45% and death rate of 7. 4 × 100 person-years (95% confidence interval (CI): 4. 8-10. 9). Overall, 50% of patients would be expected to die within 8 years of WE episode and main causes of death included serious bacterial infections (44. 5%) and cancer (33. 3%). Conclusions: Survival of patients with an alcohol-related Wernicke-Korsakoff syndrome is poor; pursuing treatment of alcohol use disorder and early diagnosis of thiamine deficiency is a priority for improving clinical outcomes.
Ajuts:	Instituto de Salud Carlos III RD12/0028/0006 Instituto de Salud Carlos III RD12/0028/0008 Instituto de Salud Carlos III RD16/0017/0003 Instituto de Salud Carlos III RD16/0017/0023 Ministerio de Educación y Ciencia PRX16/00147
Nota:	Altres ajuts: MSSSI/EC11-042
Nota:	Altres ajuts: MSSSI/PNSD2014
Nota:	Altres ajuts: MSSSI/PNSD2015
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Alcohol and alcoholism, Vol. 52 n. 4 (July 2017) , ISSN 0735-0414

Adreça alternativa: https://scholar.google.cat/scholar?q=Long-Term+Mortality+of+Patients+with
DOI: 10.1093/alcalc/agx013

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