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Comparison of two discrimination indexes in the categorisation of continuous predictors in time-to-event studies
Barrio Beraza, Irantzu (Universidad del País Vasco. Departamento de Matemática Aplicada, Estadística e Investigación Operativa)
Rodríguez-Álvarez, María Xosé (Universidade de Vigo. Departamento de Estadística e Investigación Operativa)
Meira-Machado, Luis (Universidade do Minho (Braga, Portugal). Centre of Mathematics and Department of Mathematics and Applications)
Esteban, Cristóbal (Hospital Galdakao-Usansolo. Servicio de Neumología)
Arostegui Madariaga, Inmaculada (Universidad del País Vasco. Departamento de Matemática Aplicada, Estadística e Investigación Operativa)

Date: 2017
Abstract: The Cox proportional hazards model is the most widely used survival prediction model for analysing time-to-event data. To measure the discrimination ability of a survival model the concordance probability index is widely used. In this work we studied and compared the performance of two different estimators of the concordance probability when a continuous predictor variable is categorised in a Cox proportional hazards regression model. In particular, we compared the c-index and the concordance probability estimator. We evaluated the empirical performance of both estimators through simulations. To categorise the predictor variable we propose a methodology which considers the maximal discrimination attained for the categorical variable. We applied this methodology to a cohort of patients with chronic obstructive pulmonary disease, in particular, we categorised the predictor variable forced expiratory volume in one second in percentage.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Categorisation ; Prediction models ; Cutpoint ; Cox model
Published in: SORT : statistics and operations research transactions, Vol. 41 Núm. 1 (January-June 2017) , p. 73-92 (Articles) , ISSN 1696-2281

Adreça original: https://www.raco.cat/index.php/SORT/article/view/326049
DOI: 10.2436/20.8080.02.51


20 p, 289.0 KB

The record appears in these collections:
Articles > Published articles > SORT
Articles > Research articles

 Record created 2017-06-23, last modified 2019-09-25



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