Conjecture regarding posttranslational modifications to the Arabidopsis type I proton-pumping pyrophosphatase (AVP1)
Pizzio, Gaston A. (Centre de Recerca en Agrigenòmica)
Hirschi, Kendal D. (Children's Nutrition Research Center)
Gaxiola, Roberto A. (Arizona State University. School of Life Sciences)

Data:	2017
Resum:	Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H+-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate Arabidopsis H+-PPase (AVP1- Arabidopsis Vacuolar Proton-pump 1) subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H+-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity.
Ajuts:	Ministerio de Economía y Competitividad IJCI-2015-25144
Nota:	Altres ajuts: RG and KH were supported by the National Science Foundation (grant no. IOS-1557890). KH's work is based in part on support by the United States Department of Agriculture, Agricultural Research Service under Agreement No. 58-3092-5-001.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	H+-PPase ; AVP1 ; Phosphorylation ; Sumoylation ; Ubiquitination ; Structural modeling
Publicat a:	Frontiers in plant science, Vol. 8 (Set. 2017) , art. 1572, ISSN 1664-462X

DOI: 10.3389/fpls.2017.01572
PMID: 28955362

13 p, 5.1 MB

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