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Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population
Esteban, Cristina (Hospital Universitari Vall d'Hebron)
Audí, Laura (Hospital Universitari Vall d'Hebron)
Carrascosa Lezcano, Antonio 1949- (Hospital Universitari Vall d'Hebron)
Fernández Cancio, Mónica (Hospital Universitari Vall d'Hebron)
Pérez-Arroyo, Annalisa (Hospital Universitari Vall d'Hebron)
Ulied, Angels (Hospital Universitari Vall d'Hebron)
Andaluz, Pilar (Hospital Universitari Vall d'Hebron)
Arjona, Rosa (Hospital Universitari Vall d'Hebron)
Albisu, Marian (Hospital Universitari Vall d'Hebron)
Clemente, María (Hospital Universitari Vall d'Hebron)
Gussinyer Canadell, Miquel (Hospital Universitari Vall d'Hebron)
Yeste Fernández, Diego (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)

Data: 2007
Resum: GH1 gene presents a complex map of single nucleotide polymorphisms (SNPs) in the entire promoter, coding and noncoding regions. The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height. A systematic GH1 gene analysis was designed in a control population of 307 adults of both sexes with height normally distributed within normal range for the same population: −2 standard deviation scores (SDS) to +2 SDS. An analysis was performed on individual and combined genotype associations with adult height. Twenty-five SNPs presented a frequency over 1%: 11 in the promoter (P1 to P11), three in the 5'UTR region (P12 to P14), one in exon 1 (P15), three in intron 1 (P16 to P18), two in intron 2 (P19 and P20), two in exon 4 (P21 and P22) and three in intron 4 (P23 to P25). Twenty-nine additional changes with frequencies under 1% were found in 29 subjects. P8, P19, P20 and P25 had not been previously described. P6, P12, P17 and P25 accounted for 6·2% of the variation in adult height (P = 0·0007) in this population with genotypes A/G at P6, G/G at P6 and A/G at P12 decreasing height SDS (−0·063 ± 0·031, −0·693 ± 0·350 and −0·489 ± 0·265, Mean ± SE) and genotypes A/T at P17 and T/G at P25 increasing height SDS (+1·094 ± 0·456 and +1·184 ± 0·432). This study established the GH1 gene sequence variation map in a normal adult height control population confirming the high density of SNPs in a relatively small gene. Our study shows that the more frequent SNPs did not significantly contribute to height determination, while only one promoter and two intronic SNPs contributed significantly to it. Studies in larger populations will have to confirm the associations and in vitro functional studies will elucidate the mechanisms involved. Systematic GH1 gene analysis in patients with growth delay and suspected GH deficiency/insufficiency will clarify whether different SNP frequencies and/or the presence of different sequence changes may be associated with phenotypes in them.
Ajuts: Instituto de Salud Carlos III FIS/RCMN/C03/08
Instituto de Salud Carlos III PI-020803
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; Versió publicada
Publicat a: Clinical Endocrinology, Vol. 66 (2 2007) , p. 258-268, ISSN 1365-2265

DOI: 10.1111/j.1365-2265.2006.02718.x
PMID: 17223997


11 p, 1.7 MB

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