New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance
Elias Puigdomenech, Ivet (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG))
Franckhauser, Sylvie (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG))
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG))

Data:	2013
Resum:	Vascular endothelial growth factor A (VEGF-A) is classically viewed as a key factor in angiogenesis and tissue remodeling. However, recent evidence suggests a potential role of this growth factor in the control of energy metabolism and adipose tissue function. In this regard, we and others have described the effects of the up and downregulation of VEGF-A in adipose tissue on the control of energy homeostasis. VEGF-A overexpression protects against diet-induced obesity and insulin resistance. The observation that VEGF-A overexpression leads to an increase in brown adipose tissue (BAT) thermogenesis and also promotes a "BAT-like" phenotype in white adipose tissue depots is of particular relevance for the understanding of the mechanisms underlying obesity development. In addition, VEGF-A may not only have pro-inflammatory but also anti-inflammatory properties, with a chemotactic activity specific for M2 anti-inflammatory macrophages. This new scientific evidence highlights the importance that VEGF-A actions on metabolism could have on the design of new treatments for obesity, insulin resistance and obesity-related disorders.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-224 Ministerio de Ciencia e Innovación SAF2008-00962 Ministerio de Ciencia e Innovación SAF2011-24698
Nota:	Altres ajuts: The work in our lab relevant to this commentary was supported by grants from EUMODIC (LSHG-CT-2006-037188).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Insulina ; Teixit adipós ; Obesitat ; VEGF-A ; Adipose tissue ; Insulin resistance ; Inflammation ; Obesity
Publicat a:	Adipocyte, Vol. 2 (april 2013) , p. 109-112, ISSN 2162-397X

DOI: 10.4161/adip.22880
PMID: 23805408

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