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Pàgina inicial > Articles > Articles publicats > Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome |
Data: | 2015 |
Resum: | Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying more important positions than others and thus being likely to be under stronger selective pressures. However, how positive selection distributes across the different parts of molecular networks is still not fully understood. Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively. In agreement with previous results, we found that genes with lower network centralities are more likely to evolve under positive selection (as inferred from divergence data). Surprisingly, polymorphism data yield results in the opposite direction than divergence data: Genes with higher centralities are more likely to have been targeted by recent positive selection during recent human evolution. Our results indicate that the relationship between centrality and the impact of adaptive evolution highly depends on the mode of positive selection and/or the evolutionary time-scale. |
Ajuts: | Ministerio de Economía y Competitividad BFU2013-43726-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1101 Ministerio de Economía y Competitividad JCI-2011-11089 Ministerio de Economía y Competitividad BFU2012-36346 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Physical protein interaction ; Protein interaction network ; Natural selection ; Positive selection ; Mammals ; Humans |
Publicat a: | Genome biology and evolution, Vol. 7, issue 4 (april 2015) , p. 1141-1154, ISSN 1759-6653 |
14 p, 654.2 KB |