Long-Term Normal Renal Function after Drastic Weight Reduction in Patients with Obesity-Related Glomerulopathy
Serra, Assumpta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navarro-Díaz, Maruja (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
López, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bancu, Ioana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Romero, Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	No long-term studies of renal function evolution in morbidly obese (MO) patients after weight loss are available. The aim of our work was to ascertain the long-term influence of drastic weight reduction on renal function in MO patients with obesity-related glomerular lesions. 92 MO patients with normal renal function and biopsy evidence of mild obesity-related glomerulopathy underwent bariatric surgery (BS) and subsequent drastic weight loss. A long-term prospective follow-up (mean duration: 76 ± 42 months) was carried out. Basal renal biopsies and basal and long-term metabolic and renal function studies were performed in all cases. Linear mixed models were applied. Blood pressure dropped early after BS and remained stable thereafter. Creatinine clearance and BMI fell in the first 2 years, rose slightly after 5 years and then remained stable. Serum creatinine and albuminuria decreased throughout the follow-up period. Renal function and albuminuria evolution showed non-significant differences in relation to the number of glomerular lesions. Drastic weight loss in BS-treated MO patients with pre-surgical normal renal function and mild obesity-related glomerular lesions is associated with short- and long-term maintenance of normal renal function and improvement in both arterial hypertension and albuminuria.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bariatric surgery ; Hypertension ; Obesity ; Kidney disease ; Proteinuria
Publicat a:	Obesity Facts, Vol. 8 (may 2015) , p. 188-199, ISSN 1662-4033

DOI: 10.1159/000431027
PMID: 25968610

12 p, 591.2 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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