Web of Science: 4 cites, Scopus: 4 cites, Google Scholar: cites,
Clinical intervals and diagnostic characteristics in a cohort of prostate cancer patients in Spain : a multicentre observational study
Bonfill, X. (Xavier) (Institut d'Investigació Biomèdica Sant Pau)
Martinez Zapata, María José (Universitat Autònoma de Barcelona)
Vernooij, Robin W. M. (Institut d'Investigació Biomèdica Sant Pau)
Sánchez, María José (Instituto de Investigación Sanitaria de Granada)
Suárez Varela, María Morales (Universitat de València. Departament de Medicina Preventiva i Salut Pública, Ciències de l'Alimentació, Toxicologia i Medicina Legal)
De la Cruz, Javier (Hospital Universitario 12 de Octubre (Madrid))
Emparanza, José Ignacio (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Ferrer Forés, Maria Montserrat (Institut Hospital del Mar d'Investigacions Mèdiques)
Pijoán, José Ignacio (Instituto de Investigación Sanitaria Biocruces Bizkaia)
Ramos Goñi, Juan M. (Health Services Research on Chronic Patients Network (REDISSEC))
Palou, Juan (Institut d'Investigació Biomèdica Sant Pau)
Schmidt, Stefanie (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Abraira, Víctor (Hospital Universitario Ramón y Cajal (Madrid))
Zamora, Javier (Hospital Universitario Ramón y Cajal (Madrid))
Universitat Autònoma de Barcelona

Data: 2015
Resum: Little is known about the healthcare process for patients with prostate cancer, mainly because hospital-based data are not routinely published. The main objective of this study was to determine the clinical characteristics of prostate cancer patients, the, diagnostic process and the factors that might influence intervals from consultation to diagnosis and from diagnosis to treatment. We conducted a multicentre, cohort study in seven hospitals in Spain. Patients' characteristics and diagnostic and therapeutic variables were obtained from hospital records and patients' structured interviews from October 2010 to September 2011. We used a multilevel logistic regression model to examine the association between patient care intervals and various variables influencing these intervals (age, BMI, educational level, ECOG, first specialist consultation, tumour stage, PSA, Gleason score, and presence of symptoms) and calculated the odds ratio (OR) and the interquartile range (IQR). To estimate the random inter-hospital variability, we used the median odds ratio (MOR). 470 patients with prostate cancer were included. Mean age was 67. 8 (SD: 7. 6) years and 75. 4 % were physically active. Tumour size was classified as T1 in 41. 0 % and as T2 in 40 % of patients, their median Gleason score was 6. 0 (IQR:1. 0), and 36. 1 % had low risk cancer according to the D'Amico classification. The median interval between first consultation and diagnosis was 89 days (IQR:123. 5) with no statistically significant variability between centres. Presence of symptoms was associated with a significantly longer interval between first consultation and diagnosis than no symptoms (OR:1. 93, 95%CI 1. 29-2. 89). The median time between diagnosis and first treatment (therapeutic interval) was 75. 0 days (IQR:78. 0) and significant variability between centres was found (MOR:2. 16, 95%CI 1. 45-4. 87). This interval was shorter in patients with a high PSA value (p = 0. 012) and a high Gleason score (p = 0. 026). Most incident prostate cancer patients in Spain are diagnosed at an early stage of an adenocarcinoma. The period to complete the diagnostic process is approximately three months whereas the therapeutic intervals vary among centres and are shorter for patients with a worse prognosis. The presence of prostatic symptoms, PSA level, and Gleason score influence all the clinical intervals differently.
Ajuts: Instituto de Salud Carlos III FIS/PS09/01204
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Prostatic neoplasms ; Male urogenital diseases ; Multicentre study ; Cohort study ; Prospective study
Publicat a: BMC Urology, Vol. 15 (july 2015) , ISSN 1471-2490

DOI: 10.1186/s12894-015-0058-x
PMID: 26134117


11 p, 409.0 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
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 Registre creat el 2018-01-31, darrera modificació el 2023-11-30



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