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N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives
Vilar Bergua, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Riba Llena, Iolanda (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vanhooren, Valerie (Rijksuniversiteit te Gent)
Dewaele, Sylviane (Rijksuniversiteit te Gent)
Libert, Claude (Rijksuniversiteit te Gent)
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Delgado Martínez, María Pilar (Universitat Autònoma de Barcelona. Departament de Medicina)

Data: 2015
Resum: Silent brain infarcts (s) are highly prevalent in the aged population and relate to the occurrence of further stroke and dementia. Serum N-glycome levels have been previously associated with aging and they might be related as well to the presence of s and age-related white matter hyperintensities. We determined the serum N-glycome profile in a cohort study comprising 972 subjects and evaluated the relationship between N-glycome levels and the presence and number of s and with age-related white matter hyperintensities grades, assessed by brain magnetic resonance imaging. Decreasing concentrations of bigalacto core-α-1,6-fucosylated biantennary glycan and increasing concentrations of branching α-1,3-fucosylated triantennary glycan remained as independent predictors of s (odds ratio 0. 4, 95% 0. 3-0. 7 and odds ratio 1. 8, 95% 1-3. 2, respectively), after controlling for the presence of age and classic vascular risk factors. A similar pattern was found to be related to an increasing number of s and white matter hyperintensities grade. N-glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Aging ; Biomarker ; N-glycome profile ; Silent brain infarct ; White matter hyperintensities
Publicat a: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 4, issue 11 (Oct. 2015) , ISSN 2047-9980

DOI: 10.1161/JAHA.115.002669
PMID: 26597154


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