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| Pàgina inicial > Articles > Articles publicats > Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder |
(Goethe-Universität Frankfurt am Main. Klinik für Psychiatrie, Psychosomatik und Psychotherapie) (Universität Würzburg. Zentrum fuer Psychische Gesundheit) (Universität Würzburg. Zentrum fuer Psychische Gesundheit) (Hospital Universitari Vall d'Hebron) (Universitat de Barcelona. Departament de Genètica) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Klinik Nürtingen. Abteilung für Psychiatrie und Psychotherapie) (Goethe-Universität Frankfurt am Main. Klinik für Psychiatrie, Psychosomatik und Psychotherapie) (Hospital Universitari Vall d'Hebron) (Donders Institute for Brain, Cognition and Behaviour (The Netherlands)) (Haukeland universitetssykehus) (Universitetet i Bergen. Senter for nevropsykiatrisk forskning) (Universitetet i Bergen)| Data: | 2016 |
| Resum: | Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P < 5. 00E-08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = -1. 66, standard error (SE) = 0. 34, P = 1. 07E-06), closely followed by rs35974940 in the neurotrimin gene (beta = 3. 23, SE = 0. 67, P = 1. 26E-06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P -value = 2. 28E-06) and the irritable dimension in cADHD (Fisher's P -value = 0. 0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. |
| Ajuts: | European Commission 643051 European Commission 602805 Ministerio de Economía y Competitividad SAF2012-33484 Ministerio de Ciencia e Innovación ISCIII/CP09/00119 Ministerio de Ciencia e Innovación ISCIII/CPII15/00023 Ministerio de Ciencia e Innovación ISCIII/PI11/00571 Ministerio de Ciencia e Innovación ISCIII/PI11/01629 Ministerio de Ciencia e Innovación ISCIII/PI12/01139 Ministerio de Ciencia e Innovación ISCIII/PI14/01700 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1357 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-0932 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | ADHD ; Aggression ; GWAS |
| Publicat a: | American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 171, issue 5 (July 2016) , p. 733-747, ISSN 1552-485X |
