A pathway-centered analysis of pig domestication and breeding in Eurasia
Leno Colorado, Jordi (Centre de Recerca en Agrigenòmica)
Hudson, Nick J. (University of Queensland. School of Agriculture and Food Science)
Reverter, Antonio (Commonwealth Scientific and Industrial Research Organisation)
Perez-Enciso, Miguel (Centre de Recerca en Agrigenòmica)

Data:	2017
Resum:	Ascertaining the molecular and physiological basis of domestication and breeding is an active area of research. Due to the current wide distribution of its wild ancestor, the wild boar, the pig (Sus scrofa) is an excellent model to study these processes, which occurred independently in East Asia and Europe ca. 9000 yr ago. Analyzing genome variability patterns in terms of metabolic pathways is attractive since it considers the impact of interrelated functions of genes, in contrast to genome-wide scans that treat genes or genome windows in isolation. To that end, we studied 40 wild boars and 123 domestic pig genomes from Asia and Europe when metabolic pathway was the unit of analysis. We computed statistical significance for differentiation (Fst) and linkage disequilibrium (nSL) statistics at the pathway level. In terms of Fst, we found 21 and 12 pathways significantly differentiated at a q -value < 0. 05 in Asia and Europe, respectively; five were shared across continents. In Asia, we found six significant pathways related to behavior, which involved essential neurotransmitters like dopamine and serotonin. Several significant pathways were interrelated and shared a variable percentage of genes. There were 12 genes present in.
Ajuts:	Agencia Estatal de Investigación AGL2016-78709-R Ministerio de Economía y Competitividad SEV-2015-0533 Ministerio de Economía y Competitividad AGL2013-41834-R
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Behavior ; Domestication ; Pathway analysis ; Pig ; Genome sequence data
Publicat a:	G3, Vol. 7 (July 2017) , p. 2171-2184, ISSN 2160-1836

DOI: 10.1534/g3.117.042671
PMID: 28500056

14 p, 2.2 MB

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