Asthma with bronchial hypersecretion : expression of mucins and toll-like receptors in sputum and blood
Crespo Lessmann, Astrid (Institut d'Investigació Biomèdica Sant Pau)
Mateus, Eder (Institut d'Investigació Biomèdica Sant Pau)
Torrejón, Montserrat (Institut d'Investigació Biomèdica Sant Pau)
Belda Soler, Alicia (Institut d'Investigació Biomèdica Sant Pau)
Giner, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Vidal, Silvia (Institut d'Investigació Biomèdica Sant Pau)
Sibila, Oriol (Institut d'Investigació Biomèdica Sant Pau)
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2017
Resum:	1) Define the clinical and inflammatory phenotype of asthma with bronchial hypersecretion of mucus. 2) Compare the type of mucin present in induced sputum (IS) of patients with and without bronchial hypersecretion. 3) Determine the expression of TLRs in IS and blood of asthmatics with and without bronchial hypersecretion. Cross-sectional study which included 43 non-smoking asthmatic patients without bronchiectasis, 19 with bronchiectasis, and 24 without bronchial hypersecretion. All patients underwent the following: IS, spirometry, fractional exhaled nitric oxide, prick test, total immunoglobulin E (IgE), and blood albumin. Analysis of mucins was determined by ELISA and expression of TLR2 and TLR4 by flow cytometry. The level of asthma control was determined by the Asthma Control Test (ACT) questionnaire and quality of life was assessed by the reduced version of the Asthma Quality of Life Questionnaire (mini-AQLQ). Asthmatics with bronchial hypersecretion were significantly older (62. 6 years vs 48. 5 years; p =0. 02); had greater severity (persistent severe asthma 94. 7% vs 29. 2%; p =0. 000); a higher proportion of nasal polyposis (36. 8% vs 8. 3%; p =0. 022); less control of asthma (73. 7% vs 8. 3%; p =0,000); a higher proportion of asthma with negative prick test (68. 4% vs 16. 6%; p =0. 001), and lower levels of IgE (113. 4 IU/mL vs 448 IU/mL; p =0. 007), compared with asthmatics without bronchial hypersecretion. Significant differences were observed neither in the expression of TLRs 2 and 4 in inflammatory cells of IS or peripheral blood, nor in the expression of mucins between both groups. Asthma patients with bronchial hypersecretion have more severe and uncontrolled disease, with poor quality of life as well as a non-allergic inflammatory phenotype. Within the mechanisms involving these differences, it does not appear that mucins and TLRs play an important role.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Asthma ; Mucins ; Inflammation ; Induced sputum ; Toll-like receptor
Publicat a:	Journal of Asthma and Allergy, Vol. 10 (october 2017) , p. 269-276, ISSN 1178-6965

DOI: 10.2147/JAA.S142200
PMID: 29066918

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