MI (2-methyl-4-isothiazolin-3-one) contained in detergents is not detectable in machine washed textiles
Hofmann, Maja A. (Charité - Universitätsmedizin Berlin)
Giménez-Arnau, Ana M.. 1961- , (Hospital del Mar (Barcelona, Catalunya))
Aberer, Werner (Medical University of Graz, Austria)
Bindslev-Jensen, Carsten (Odense Research Center for Anaphylaxis)
Zuberbier, Torsten (Charité - Universitätsmedizin Berlin)
Universitat Autònoma de Barcelona

Data:	2018
Resum:	European legislation has banned the preservative methylisothiazolinone (MI) from inclusion in leave-on cosmetics. However, the risk for allergic reactions depends on exposure. The aim of this study was to determine the risk of MI in laundry detergents for household machine washing. Different formulations of laundry detergents with commercial MI levels, up to one thousand ppm were used and three different types of clothes were washed in a normal household machine setting one time and 10 times. The level of MI was measured by HPLC. While MI could be retrieved in the positive control of clothes drenched with washing powder but not washed afterwards, MI could not be detected in any specimen of clothes washed under household conditions. The detection limit was 0. 5 ppm. It is important to discuss the difference of risk and hazard. While MI clearly is a high hazard as a strong contact allergen, the risk depends on exposure. Regarding the risk of exposure levels for the consumer to MI in clothes it can be stated that the use of MI in laundry detergents is safe for the consumer if these products are used according to the instructions in the normal household setting machine wash.
Nota:	Altres ajuts: Funding - The study was supported by the European Centre for Allergy Research Foundation.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	MI ; Laundry detergent ; Preservative ; Contact allergy
Publicat a:	Clinical and translational allergy, Vol. 8 (january 2018) , ISSN 2045-7022

DOI: 10.1186/s13601-017-0187-2
PMID: 29312657

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