Assessment of the influence of direct tobacco smoke on infection and active TB management
Altet, Neus (Hospital Universitari Vall d'Hebron)
Latorre, Irene ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron)
Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Molina Romero, Israel ![Identificador ORCID](/img/uab/orcid.ico)
(Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Milà, Celia (Hospital Universitari Vall d'Hebron)
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muriel-Moreno, Beatriz
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Villar-Hernández, Raquel
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Laabei, Maisem
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gómez Camacho, Andromeda Celeste
(Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Godoy, Pere
(Generalitat de Catalunya. Departament de Salut)
De Souza Galvão, Maria Luiza
(Hospital Universitari Vall d'Hebron)
Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón)
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo)
Domínguez, José
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
PII Smoking SEPAR Working Group
Data: |
2017 |
Resum: |
Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs). Objective. In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs. Methods. A total of 525 participants were studied: (i) 175 active pulmonary TB patients and (ii) 350 individuals coming from contact tracing studies, 41 of whom were secondary TB cases. Clinical, radiological and microbiological data were collected. T-SPOT. TB and QFN-G-IT were processed according manufacturer's instructions. Results. In smoking patients with active TB, QFN-G-IT (34. 4%) and T-SPOT. TB (19. 5%) had high frequencies of negative results. In addition, by means of an unconditional logistic regression,smoking was a main factor associated with IGRAs' false-negative results (aOR: 3. 35; 95% CI:1. 47±7. 61; p<0. 05). Smoking patients with active TB presented a high probability of having cavitary lesions (aOR: 1. 88; 95%CI:1. 02±3. 46;p<0. 05). Mean culture negativization (months) ± standard deviation (SD) was higher in smokers than in non-smokers (2. 47±1. 3 versus 1. 69±1. 4). Latent TB infection (LTBI) was favored in smoking contacts, being a risk factor associated with infection (aOR: 11. 57; 95%CI:5. 97±22. 41; p<0. 00005). The IFN-γ response was significantly higher in non-smokers than in smokers. Smoking quantity and IFN-γ response analyzed by IGRAs were dose-dependent related. Conclusions. Smoking had a negative effect on radiological manifestations, delaying time of sputum conversion. Our data establish a link between tobacco smoking and TB due to a weakened IFN- γ response caused by direct tobacco smoke. |
Ajuts: |
Instituto de Salud Carlos III PI 13/01546 Instituto de Salud Carlos III PI 16/01912
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Drets: |
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Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Publicat a: |
PloS one, Vol. 12 Núm. 8 (august 2017) , p. 1, ISSN 1932-6203 |
DOI: 10.1371/journal.pone.0182998
PMID: 28837570
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Registre creat el 2018-10-25, darrera modificació el 2023-12-05