Giant tortoise genomes provide insights into longevity and age-related disease
Quesada, Víctor (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Freitas Rodríguez, Sandra (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Miller, Joshua (Yale University. Department of Ecology and Evolutionary Biology)
Pérez-Silva, José G. (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Jiang, Zi-Feng (The University of Chicago. Institute for Genomics and Systems Biology)
Tapia, Washington (Galapagos Islands. Galapagos National Park Directorate)
Santiago-Fernández, Olaya (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Campos-Iglesias, Diana (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Kuderna, Lukas (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona))
Quinzin, Maud (Yale University. Department of Ecology and Evolutionary Biology)
García Álvarez, Miguel (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Carrero, Dido (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Beheregaray, Luciano B. (Flinders University. College of Science and Engineering)
Gibbs, James P. (State University of New York. College of Environmental Science and Forestry)
Chiari, Ylenia (University of South Alabama. Department of Biology)
Glaberman, Scott (University of South Alabama. Department of Biology)
Ciofi, Claudio (University of Florence. Department of Biology)
Araujo-Voces, Miguel (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Mayoral, Pablo (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Arango, Javier R. (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Tamargo-Gómez, Isaac (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Roiz-Valle, David (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Pascual-Torner, María (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Evans, Benjamin R. (Yale University. Department of Ecology and Evolutionary Biology)
Edwards, Danielle L. (University of California. School of Natural Sciences)
Garrick, Ryan C. (University of Mississippi. Department of Biology)
Russello, Michael A. (The University of British Columbia. Department of Biology)
Poulakakis, Nikos (University of Crete. Department of Biology)
Gaughran, Stephen J. (Yale University. Department of Ecology and Evolutionary Biology)
Rueda, Danny O. (Galapagos Islands. Galapagos National Park Directorate)
Bretones, Gabriel (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)
Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont)
White, Kevin P. (The University of Chicago. Institute for Genomics and Systems Biology)
Caccone, Adalgisa (Yale University. Department of Ecology and Evolutionary Biology)
López-Otín, Carlos (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular)

Data:	2018
Resum:	Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George-the iconic last member of Chelonoidis abingdonii-and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.
Ajuts:	Ministerio de Economía y Competitividad BFU2014-55090-P Ministerio de Economía y Competitividad BFU2017-86471-P
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Comparative genomics ; Molecular evolution
Publicat a:	Nature ecology & evolution, (December 2018) , ISSN 2397-334X

DOI: 10.1038/s41559-018-0733-x
PMID: 30510174

12 p, 1.7 MB

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