COMT-by-sex interaction effect on psychosis proneness
De Castro-Catala, Marta (Universitat de Barcelona. Departament de Biologia Animal)
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Sheinbaum Frank, Tamara (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Moreno-Fortuny, Artal (Universitat de Barcelona. Departament de Biologia Animal)
Kwapil, Thomas (University of North Carolina at Greensboro. Department of Psychology)
Rosa, Araceli (Universitat de Barcelona. Departament de Biologia Animal)

Data:	2015
Resum:	Schizotypy phenotypes in the general population share etiopathogenic mechanisms and risk factors with schizophrenia, supporting the notion of psychosis as a continuum ranging from nonclinical to clinical deviance. Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex. Several recent studies have reported a sex difference in the impact of COMT genotype on psychiatric and cognitive phenotypes and personality traits. The present study investigated the association of COMT Val158Met (rs4680) with psychometric positive and negative schizotypy and psychotic experiences in a sample of 808 nonclinical young adults. The main finding was that sex moderates the association of COMT genotype with the negative dimension of both schizotypy and psychotic experiences. Male subjects carrying the Val allele tended to score higher on the negative dimension of both trait and symptom-like measures. The results from the present study are consistent with recent work suggesting an association between negative schizotypy and diminished prefrontal dopamine availability. They support the idea that a biological differentiation underlies the positive and negative schizotypy dimensions. Additionally, these findings contribute to the growing literature on sex-specific effects of COMT on the predisposition to psychiatric disorders and personality traits.
Ajuts:	Ministerio de Economía y Competitividad PSI2011-30321-C02-01 Ministerio de Economía y Competitividad PSI2011-30321-C02-02 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR1070 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR1636
Nota:	Altres ajuts: La Marató de TV3 (091110)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult ; Alleles ; Catechol O-Methyltransferase ; Dopamine ; Female ; Genetic predisposition to disease ; Genotype ; Humans ; Male ; Polymorphism, single nucleotide ; Prefrontal cortex ; Psychotic disorders ; Schizophrenia ; Sex characteristics ; Young adult
Publicat a:	BioMed Research International, Vol. 2015 (2015) , art. 829237, ISSN 2314-6141

DOI: 10.1155/2015/829237
PMID: 25722988

8 p, 1.3 MB

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