Boosted Regeneration and Reduced Denervated Muscle Atrophy by NeuroHeal in a Pre-clinical Model of Lumbar Root Avulsion with Delayed Reimplantation

Web of Science: 18 cites, Scopus: 20 cites, Google Scholar: cites,

(Universitat Autònoma de Barcelona. Institut de Neurociències)
Forés Vineta, Joaquim

(Hospital Clínic i Provincial de Barcelona)
Navarro, X. (Xavier)

(Universitat Autònoma de Barcelona. Institut de Neurociències)
Casas Louzao, Caty

(Universitat Autònoma de Barcelona. Institut de Neurociències)

Data:	2017
Resum:	The "gold standard" treatment of patients with spinal root injuries consists of delayed surgical reconnection of nerves. The sooner, the better, but problems such as injury-induced motor neuronal death and muscle atrophy due to long-term denervation mean that normal movement is not restored. Herein we describe a preclinical model of root avulsion with delayed reimplantation of lumbar roots that was used to establish a new adjuvant pharmacological treatment. Chronic treatment (up to 6 months) with NeuroHeal, a new combination drug therapy identified using a systems biology approach, exerted long-lasting neuroprotection, reduced gliosis and matrix proteoglycan content, accelerated nerve regeneration by activating the AKT pathway, promoted the formation of functional neuromuscular junctions, and reduced denervation-induced muscular atrophy. Thus, NeuroHeal is a promising treatment for spinal nerve root injuries and axonal regeneration after trauma.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Scientific reports, Vol. 7 (2017) , art. 12028, ISSN 2045-2322

12 p, 7.4 MB

Registre creat el 2019-06-18, darrera modificació el 2025-05-27