On the importance to acknowledge transposable elements in epigenomic analyses
Lerat, Emmanuelle (Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive)
Casacuberta i Suñer, Josep M. 1962- (Centre de Recerca en Agrigenòmica)
Chaparro, Cristian (University of Perpignan Via Domitia)
Vieira, Cristina (Université de Lyon. Laboratoire de Biométrie et Biologie Evolutive)

Data:	2019
Resum:	Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could allow a rapid phenotypic adaptation to global environmental changes. In this review, we argue the crucial need to take into account the repeated part of genomes when studying the global impact of epigenetic modifications on an organism. We emphasize more particularly why it is important to carefully consider TEs and what bioinformatic tools can be used to do so.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Transposable element ; Epigenomics ; Bioinformatic tools
Publicat a:	Genes, Vol. 10, Issue 4 (April 2019) , art. 258, ISSN 2073-4425

DOI: 10.3390/genes10040258
PMID: 30935103

18 p, 287.1 KB

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