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Pàgina inicial > Articles > Articles publicats > Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease |
Data: | 2019 |
Resum: | Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO₂NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. The aim of the current investigation was to elucidate whether CeO₂NPs display beneficial effects in an experimental model of NAFLD. Therefore, fifteen Wistar rats were subjected to a methionine and choline deficient diet (MCDD) for 6 weeks and intravenously treated with CeO₂NPs or vehicle during the weeks three and four of the diet. The effect of CeO₂NPs on serum biochemistry, hepatic steatosis, inflammation, fatty acid content and expression of reactive oxygen species (ROS) and lipid metabolism related genes was assessed. MCDD fed rats showed increased inflammation, enhanced hepatic lipid accumulation of both saturated and unsaturated fatty acids (FAs) and overexpression of genes related to fatty liver and ROS metabolism. Treatment with CeONPs was able to reduce the size and content of hepatocyte lipid droplets, the hepatic concentration of triglyceride- and cholesterol ester-derived FAs and the expression of several genes involved in cytokine, adipokine and chemokine signaling pathways. These findings suggest that CeO₂NPs could be of beneficial value in NAFLD. |
Ajuts: | Ministerio de Ciencia e Innovación SAFRTI2018-094734-B-C21 Ministerio de Ciencia e Innovación SAF2016-75358-R Ministerio de Economía y Competitividad P74844I/15/00777 Ministerio de Economía y Competitividad SAF2015-64126R Ministerio de Economía y Competitividad BES-2013-063685 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-219 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Biologics ; Nanoparticles ; Non-alcoholic fatty liver disease |
Publicat a: | Scientific reports, Vol. 9 (2019) , art. 12848, ISSN 2045-2322 |
20 p, 2.6 MB |