visitant ::
identificació
|
|||||||||||||||
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español |
Pàgina inicial > Articles > Articles publicats > Versatile iron-catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy |
Data: | 2019 |
Resum: | A novel chemical approach integrating the benefits of nanoparticles with versatility of coordination chemistry is reported herein to increase the effectiveness of well-known HIV antiretroviral drugs. The novelty of our approach is illustrated using a catechol ligand tethered to the known antiretroviral azidothymidine (AZT) as a constitutive building block of the nanoparticles. The resulting nanoscale coordination polymers (NCPs) ensure good encapsulation yields and equivalent antiretroviral activity while significantly diminishing its cytotoxicity. Moreover, this novel family of nanoparticles also offers (i) long-lasting drug release that is dissimilar inside and outside the cells depending on pH, (ii) triggered release in the presence of esterases, activating the antiviral activity in an on-off manner due to a proper chemical design of the ligand and (iii) improved colloidal stabilities and cellular uptakes (up to 50-fold increase). The presence of iron nodes also adds multifunctionality as possible contrast agents. The present study demonstrates the suitability of NCPs bearing pharmacologically active ligands as an alternative to conventional antiretroviral treatments. |
Ajuts: | Ministerio de Economía y Competitividad MAT2015-70615-R Ministerio de Economía y Competitividad MAT2012-35324 Ministerio de Economía y Competitividad CTQ2013-44161-R Ministerio de Economía y Competitividad CTQ2016-75363-R Ministerio de Economía y Competitividad BIO2016-78057-R Instituto de Salud Carlos III RD16/0025/0002 Ministerio de Economía y Competitividad SEV-2013-0295 |
Drets: | Tots els drets reservats. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió sotmesa a revisió |
Matèria: | Antiretroviral drugs ; Antiretroviral treatment ; Antiviral activities ; Co-ordination chemistries ; Colloidal Stability ; Coordination Polymers ; Encapsulation yields ; Ligand functionalization ; Anti-HIV Agents ; Catechols ; Cell Line ; Drug Carriers ; Drug Liberation ; Drug Stability ; HIV Infections ; HIV-1 ; Humans ; Ligands ; Nanoparticles ; Polymers ; Zidovudine |
Publicat a: | Biomaterials science, Vol. 7, Issue 1 (January 2019) , p. 178-186, ISSN 2047-4849 |
Preprint 9 p, 1.1 MB |