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Pàgina inicial > Articles > Articles publicats > Optimizing the limit of detection of waveguide-based interferometric biosensor devices |
Data: | 2019 |
Resum: | Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i. e. , the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ~10 RIU with a silicon nitride sensor operating at telecom wavelengths. |
Ajuts: | European Commission 713721 Ministerio de Economía y Competitividad TEC2016-80718-R Ministerio de Economía y Competitividad SEV-2017-0706 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Limit of detection ; Coherent detection ; Silicon photonics ; Interferometer ; Biosensors |
Publicat a: | Sensors (Basel, Switzerland), Vol. 19, Issue 17 (September 2019) , art. 3671, ISSN 1424-8220 |
13 p, 1.4 MB |