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Pàgina inicial > Articles > Articles publicats > Influence of Gut Microbiota on Progression to Tuberculosis Generated by High Fat Diet-Induced Obesity in C3HeB/FeJ Mice |
Data: | 2019 |
Resum: | The administration of a high fat content diet is an accelerating factor for metabolic syndrome, impaired glucose tolerance, and early type 2 diabetes. The present study aims to assess the impact of a high fat diet on tuberculosis progression and microbiota composition in an experimental animal model using a C3HeB/FeJ mouse strain submitted to single or multiple consecutive aerosol infections. These models allowed us to study the protection induced by Bacillus Calmette-Guérin vaccination as well as by the natural immunity induced by chemotherapy after a low dose Mycobacterium tuberculosis infection. Our results show that a high fat diet is able to trigger a pro-inflammatory response, which results in a faster progression toward active tuberculosis and an impaired protective effect of BCG vaccination, which is not the case for natural immunity. This may be related to dysbiosis and a reduction in the Firmicutes/Bacteroidetes ratio in the gut microbiota caused by a decrease in the abundance of the Porphyromonadaceae family and, in particular, the Barnesiella genus. It should also be noted that a high fat diet is also related to an increase in the genera Alistipes, Parasuterella, Mucispirillum, and Akkermansia, which have previously been related to dysbiotic processes. As diabetes mellitus type 2 is a risk factor for developing tuberculosis, these findings may prove useful in the search for new prophylactic strategies for this population subset. |
Ajuts: | European Commission 643381 European Commission 638553 Ministerio de Economía y Competitividad SAF2017-92345-EXP Instituto de Salud Carlos III CPII18/00031 Ministerio de Economía y Competitividad BES-2014-071066 Instituto de Salud Carlos III IFI14/00015 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-500 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Tuberculosis ; High fat diet ; Obesity ; Comorbidity ; BCG ; Mice ; Gut microbiota ; C3HeB/FeJ |
Publicat a: | Frontiers in immunology, Vol. 10 (October 2019) , art. 2464, ISSN 1664-3224 |
18 p, 5.0 MB |