Toenail concentrations of trace elements and occupational history in pancreatic cancer
Camargo Sanromà, Judit (Institut Hospital del Mar d'Investigacions Mèdiques)
Pumarega, José Antonio (Institut Hospital del Mar d'Investigacions Mèdiques)
Alguacil, Juan (Universidad de Huelva)
Sanz-Gallén, Pere (Hospital Clínic i Provincial de Barcelona)
Gasull, Magda (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Delclos, George L. (Institut Hospital del Mar d'Investigacions Mèdiques)
Amaral, André F. S. (Imperial College London)
Porta, Miquel 1957- (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)

Data:	2019
Resum:	Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, and chromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies have assessed whether body concentrations of such compounds differed among subjects occupationally exposed and unexposed. No studies which found that exposure to such metals increased the risk of EPC assessed whether past occupations were the source of exposure. Objective: The aim was to analyse the relationship between toenail concentrations of trace elements and occupational history in EPC patients. Methods: The study included 114 EPC cases personally interviewed on occupational history and lifestyle factors. Occupations were coded according to the International Standard Classification of Occupations 1988. Selected occupational exposures were assessed by two industrial hygienists and with the Finnish job-exposure matrix (Finjem). Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. Adjusted geometric means (aGMs) and 95% confidence intervals (95% CI) were calculated. Results: Patients occupationally exposed to aromatic hydrocarbon solvents (AHs) had higher concentrations of cadmium, manganese, lead, iron and vanadium. The aGM of cadmium concentrations for cases exposed to any pesticide was 0. 056 μg/g [95% CI: 0. 029-0. 108], and, for unexposed cases, 0. 023 μg/g [0. 017-0. 031]. Patients occupationally exposed to pesticides had higher concentrations of cadmium and manganese. Higher concentrations of vanadium, lead and arsenic were related to exposure to formaldehyde. Vanadium and lead were also associated with exposure to chlorinated hydrocarbon solvents, and arsenic was related to exposure to polycyclic aromatic hydrocarbons (PAHs). Conclusions: Patients occupationally exposed to AHs, pesticides, chlorinated hydrocarbon solvents, formaldehyde, volatile sulphur compounds and PAHs had higher concentrations of several metals. These elements may account for some of the occupational risks previously reported for pancreatic cancer.
Ajuts:	Instituto de Salud Carlos III PI13-00020 Instituto de Salud Carlos III PI17-00088 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1350 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1012 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-439
Nota:	Altres ajuts: Fundació La Marató de TV3 (20132910).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Arsenic ; Cadmium ; Manganese ; Occupation ; Pancreatic càncer ; Trace elements
Publicat a:	Environment International, Vol. 127 (june 2019) , p. 216-225, ISSN 1873-6750

DOI: 10.1016/j.envint.2019.03.037
PMID: 30928845

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