Endometrial stromal cells circulate in the bloodstream of women with endometriosis : A pilot study
Vallvé-Juanico, J. (Center for Reproductive Sciences. Department of Obstetrics. Gynecology and Reproductive Sciences. University of California)
López-Gil, C. (Hospital Universitari Vall d'Hebron)
Ballesteros, Agustín (IVIRMA-Barcelona. Departamento de Medicina Reproductiva)
Santamaria, X. (Igenomix Foundation)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Endometriosis is characterized by the presence of endometrial tissue outside the uterus. While endometriotic tissue is commonly localized in the pelvic cavity, it can also be found in distant sites, including the brain. The origin and pathophysiology of tissue migration is poorly understood; retrograde menstruation is thought to be the cause, although the presence of endometrium at distant sites is not explained by this hypothesis. To determine whether dissemination occurs via the bloodstream in women with endometriosis, we analyzed circulating blood for the presence of endometrial cells. Circulating endometrial stromal cells were identified only in women with endometriosis but not in controls, while endometrial epithelial cells were not identified in the circulation of either group. Our results support the hypothesis that endometrial stromal cells may migrate through circulation and promote the pathophysiology of endometriosis. The detection of these cells in circulation creates avenues for the development of less invasive diagnostic tools for the disease, and opens possibilities for further study of the origin of endometriosis.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca DI2015_074
Nota:	Funding: This research was funded by a Centro de Desarrollo Tecnológico Industrial (CDTI) grant (IDI-2013039). The Industrial Doctorate AGAUR (Agency for Administration of University and Research Grants, Catalonia, Spain) also supported this work (DI2015_074).
Nota:	Altres ajuts: CDTI/IDI-2013039
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Endometriosis ; Circulating endometrial cells ; CD10 ; Stromal cells ; Diagnostics ; Liquid biopsy
Publicat a:	International journal of molecular sciences, Vol. 20 Núm. 15 (january 2019) , p. 3740, ISSN 1422-0067

DOI: 10.3390/ijms20153740
PMID: 31370190

12 p, 1.1 MB

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