Web of Science: 13 cites, Scopus: 14 cites, Google Scholar: cites,
Measurement properties of the online EuroQol-5D-youth instrument in children and adolescents with type 1 diabetes mellitus : Questionnaire study
Mayoral, K. (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Rajmil, L. (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Garin, O. (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Pont, A. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Alonso, J (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Carreras, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Herrero, Francisco Javier (Corporació de Salut del Maresme i la Selva. Hospital de Calella)
Mengibar, J. M. (Corporació de Salut del Maresme i la Selva. Hospital de Blanes)
Rodriguez-Arjona, D. (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Ravens-Sieberer, Ulrike (Department of Child and Adolescent Psychiatry. Psychotherapy. and Psychosomatics. University Medical Center Hamburg - Eppendorf)
Raat, Hein (Department of Public Health. Erasmus University Medical Center Rotterdam)
Serra-Sutton, V. (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Ferrer, M. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)

Data: 2019
Resum: Background: The lack of continuity between health-related quality of life (HRQoL) instruments designed for children and adults hinders change analysis with a life course approach. To resolve this gap, EuroQol (EQ) developed the EQ-5D-Youth (EQ-5D-Y), derived from the EQ-5D for adults. Few studies have assessed the metric properties of EQ-5D-Y in children with specific chronic conditions, and none have done so for children with type I diabetes mellitus (T1DM). Objective: This study aimed to evaluate the acceptability, validity, reliability, and responsiveness of the EQ-5D-Y in children and adolescents with T1DM, when administered online. Methods: Participants with T1DM were consecutively recruited from July to December 2014, from a list of potential candidates aged 8-19 years, who attended outpatient pediatric endocrinology units. Before every quarterly routine visit, participants received an email/telephone reminder to complete the online version of two generic HRQoL questionnaires: EQ-5D-Y and KIDSCREEN-27. The EQ-5D-Y measures five dimensions, from which an equally weighted summary score was constructed (range: 0-100). Completion rate and distribution statistics were calculated. Construct validity was evaluated through known group comparisons based on general health, acute diabetic decompensations, mental health, family function, and a multitrait, multimethod matrix between EQ-5D-Y and KIDSCREEN by using Spearman correlations. Construct validity hypotheses were stated a priori. Reliability was assessed with the intraclass correlation coefficient and responsiveness by testing changes over time and calculating the effect size. Reliability and responsiveness were tested among the stable and improved subsamples defined by a KIDSCREEN-10 index change of <4. 5 points or ≥4. 5 points, respectively, from the first to the fourth visit. Results: Of the 136 participants, 119 (87. 5%) responded to the EQ-5D-Y at the last visit. The dimensions that showed higher percentages of participants with problems were "having pain/discomfort" (34. 6%) and "worried/sad/unhappy" (28. 7%). The mean (SD) of the EQ-5D-Y summary score was 8. 5 (10. 9), with ceiling and floor effects of 50. 7% and 0%, respectively. Statistically significant HRQoL differences between groups defined by their general health (excellent/very good and good/regular/bad) and mental health (Strengths and Difficulties Questionnaire score ≤15 and >16, respectively) were found in three EQ-5D-Y dimensions ("doing usual activities," "having pain/discomfort," and "feeling worried/sad/unhappy"), summary score (effect size for general health and mental health groups=0. 7 and 1. 5, respectively), and KIDSCREEN-10 index (effect size for general health and mental health groups=0. 6 and 0. 9, respectively). Significant differences in the EQ-5D-Y dimensions were also found according to acute diabetic decompensations in "looking after myself" (P=. 005) and according to family function in "having pain/discomfort" (P=. 03). Results of the multitrait, multimethod matrix confirmed three of the four relationships hypothesized as substantial (0. 21, 0. 58, 0. 50, and 0. 46). The EQ-5D-Y summary score presented an intraclass correlation coefficient of 0. 83. Statistically significant change between visits was observed in the improved subsample, with an effect size of 0. 7 (P<. 001). Conclusions: These results support the use of the EQ-5D-Y administered online as an acceptable, valid, reliable, and responsive instrument for evaluating HRQoL in children and adolescents with T1DM.
Ajuts: Instituto de Salud Carlos III PI12-01296
Instituto de Salud Carlos III FI16-00071
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR452
Nota: Montse Ferrer, MPH, PhD, MD Health Services Research Group Hospital del Mar Medical Research Institute Doctor Aiguader, 88 Office 144 Barcelona, 08003 Spain Phone: 34 933160763 Email: mferrer@imim.es
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: EQ-5D-Y ; EuroQol ; Health-related quality of life ; Type 1 diabetes ; Validity
Publicat a: Journal of medical Internet research, Vol. 21 Núm. 11 (2019) , p. e14947, ISSN 1438-8871

DOI: 10.2196/14947
PMID: 31714252


14 p, 127.3 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació Biomèdica Sant Pau
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 Registre creat el 2020-06-03, darrera modificació el 2023-01-15



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