1H-NMR urinary metabolic profile, a promising tool for the management of infants with human cytomegalovirus-infection
Frick, Marie Antoinette (Red de Investigación Translacional en Infectología Pediátrica (RITIP))
Barba, Ignasi (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Fenoy-Alejandre, M. (Hospital Universitari Vall d'Hebron)
López-López, Paula (Vall d'Hebron Institut de Recerca (VHIR))
Baquero-Artigao, Fernando (Hospital Universitario La Paz (Madrid))
Rodríguez-Molino, Paula (Hospital Universitario La Paz (Madrid))
Noguera-Julian, Antoni (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Nicolás-López, Marta (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
de la Fuente-Juárez, Asunción (Hospital Quirónsalud Barcelona. Departament de Pediatria)
Codina, María Gema (Hospital Universitari Vall d'Hebron)
Esperalba, Juliana (Hospital Universitari Vall d'Hebron)
Linde-Sillo, Ángeles (Hospital Universitari Vall d'Hebron)
Soler-Palacín, Pere (Red de Investigación Translacional en Infectología Pediátrica (RITIP))

Data:	2019
Resum:	Congenital human cytomegalovirus (HCMV) infection is the most common mother-to-child transmitted infection in the developed world. Certain aspects of its management remain a challenge. Urinary metabolic profiling is a promising tool for use in pediatric conditions. The aim of this study was to investigate the urinary metabolic profile in HCMV-infected infants and controls during acute care hospitalization. Urine samples were collected from 53 patients at five hospitals participating in the Spanish congenital HCMV registry. Thirty-one cases of HCMV infection and 22 uninfected controls were included. Proton nuclear magnetic resonance (H-NMR) spectra were obtained using NOESYPR1D pulse sequence. The dataset underwent orthogonal projection on latent structures discriminant analysis to identify candidate variables affecting the urinary metabolome: HCMV infection, type of infection, sex, chronological age, gestational age, type of delivery, twins, and diet. Statistically significant discriminative models were obtained only for HCMV infection (p = 0. 03) and chronological age (p < 0. 01). No significant differences in the metabolomic profile were found between congenital and postnatal HCMV infection. When the HCMV-infected group was analyzed according to chronological age, a statistically significant model was obtained only in the neonatal group (p = 0. 01), with the differentiating metabolites being betaine, glycine, alanine, and dimethylamine. Despite.
Nota:	Funding: This study was supported by the Spanish Society of Pediatric Infectious Diseases (José María Corretger grant, 2016).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Metabolites, Vol. 9 Núm. 12 (december 2019) , p. 288, ISSN 2218-1989

DOI: 10.3390/metabo9120288
PMID: 31775291

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