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Psychosocial problems in women attending French, German and Spanish genetics clinics before and after targeted or multigene testing results : an observational prospective study
Brédart, Anne (Université Paris Descartes)
Kop, Jean-Luc (Université de Lorraine. Département de Psychologie)
Dick, Julia (Cancer Center Cologne)
Cano, Alejandra (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
De Pauw, Antoine (Institut Curie)
Anota, Amélie (Centre Hospitalier Régional Universitaire de Besançon)
Brunet, Joan (Institut Català d'Oncologia)
Devilee, Peter (Leiden University Medical Center)
Stoppa-Lyonnet, Dominique (Institut Curie)
Schmutzler, Rita (Cologne University Hospital)
Dolbeault, Sylvie (Université Paris-Saclay)

Date: 2019
Abstract: Objectives and setting Advances in multigene panel testing for cancer susceptibility has increased the complexity of counselling, requiring particular attention to counselees' psychosocial needs. Changes in psychosocial problems before and after genetic testing were prospectively compared between genetic test results in women tested for breast or ovarian cancer genetic susceptibility in French, German and Spanish clinics. Participants and measures Among 752 counselees consecutively approached, 646 (86%) were assessed after the initial genetic consultation (T1), including 510 (68%) affected with breast cancer, of which 460 (61%) were assessed again after receiving the test result (T2), using questionnaires addressing genetic-specific psychosocial problems (Psychosocial Aspects of Hereditary Cancer (PAHC)-six scales). Sociodemographic and clinical data were also collected. Results Seventy-nine (17. 2%), 19 (4. 1%), 259 (56. 3%), 44 (9. 6%) and 59 (12. 8%) women received a BRCA1/2, another high/moderate-risk pathogenic variant (PV), negative uninformative, true negative (TN) or variant of uncertain significance result (VUS), respectively. On multiple regression analyses, compared with women receiving another result, those with a VUS decreased more in psychosocial problems related to hereditary predisposition (eg, coping with the test result) (ß=-0. 11, p<0. 05) and familial/social issues (eg, risk communication) (ß=-0. 13, p<0. 05), almost independently from their problems before testing. Women with a PV presented no change in hereditary predisposition problems and, so as women with a TN result, a non-significant increase in familial/social issues. Other PAHC scales (ie, emotions, familial cancer, personal cancer and children-related issues) were not affected by genetic testing. Conclusions In women tested for breast or ovarian cancer genetic risk in European genetics clinics, psychosocial problems were mostly unaffected by genetic testing. Apart from women receiving a VUS result, those with another test result presented unchanged needs in counselling in particular about hereditary predisposition and familial/social issues.
Note: Altres ajuts: Ile-de-France Cancer Pole: 2015-1-EMERG-14-ICH-1; SiRIC label Institut Curie
Note: Número d'acord de subvenció EC/H2020/634935
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Published in: BMJ open, Vol. 9, núm. 9 (2019) , p. e029926, ISSN 2044-6055

DOI: 10.1136/bmjopen-2019-029926
PMID: 31551380


12 p, 432.6 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2020-06-03, last modified 2020-11-07



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