Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture : A substudy protocol of the hip fracture Accelerated surgical TreaTment and Care tracK (HIP ATTACK) international randomised controlled trial
Kessler Borges, Flavia (Department of Perioperative Medicine. Population Health Research Institute (Ontario, Canadà))
Devereaux, Philip James (Departments of Health Research Methods. Evidence. and Impact (HEI). McMaster University (Ontario, Canadà))
Cuerden, Meaghan (Western University (Ontario, Canadà))
Bhandari, Mohit (McMaster University (Ontario, Canadà))
Guerra-Farfán, Ernesto (Hospital Universitari Vall d'Hebron)
Patel, Ameen (McMaster University (Ontario, Canadà))
Sigamani, Alben (Clinical Research, Narayana Hrudayalaya Limited (Bangalore, Índia))
Umer, Massod (Aga Khan University (Karachi, Pakistan))
Neary, John (McMaster University (Ontario, Canadà))
Tiboni, Maria (McMaster University (Ontario, Canadà))
Tandon, Vikas (McMaster University (Ontario, Canadà))
Ramokgopa, Mmampapatla Thomas (University of the Witwatersrand (Johannesburg, Sud-àfrica))
Sancheti, Parag (Sancheti Institute for Orthopaedics and Rehabilitation (Pune, Índia))
John, Bobby (Christian Medical College. Hospital Ludhiana (Ludhiana, Índia))
Lawendy, AbdelRahman (Western University (Ontario, Canadà))
Balaguer Castro, Mariano (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Jenkinson, Richard (Sunnybrook Health Sciences Centre (Ontario, Canadà))
Ślȩczka, Pawel (Orthopaedic Department. SPZOZ (Myslenice, Polònia))
Nabi Nur, Aamer (Shifa International Hospital (Islamabad, Pakistan))
Wood, Gavin C. A. (Queen's University (Ontario, Canadà))
Feibel, Robert (Division of Orthopaedic Surgery. University of Ottawa (Ontario, Canadà))
McMahon, John Stephen (Markham Stouffville Hospital (Ontario, Canadà))
Sigamani, Alen (Government TD Medical College (Allapuzha, Índia))
Biccard, Bruce M (University of Cape Town (Rondebosch, Sud-àfrica))
Landoni, Giovanni (Vita-Salute San Raffaele University (Milà, Itàlia))
Szczeklik, Wojciech (Jagiellonian University. Medical College (Krakow, Polònia))
Wang, Chew Yin (University Malaya (Kuala Lumpur, Malàisia))
Tomas-Hernandez, Jordi (Hospital Universitari Vall d'Hebron)
Abraham, Valsa (Christian Medical College. Hospital Ludhiana (Ludhiana, Índia))
Vincent, Jessica (Population Health Research Institute (Ontario, Canadà))
Harvey, Valerie (Population Health Research Institute (Ontario, Canadà))
Pettit, Shirley (Population Health Research Institute (Ontario, Canadà))
Sontrop, Jessica M. (Western University (Ontario, Canadà))
Garg, Amit (Western University (Ontario, Canadà))
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Introduction Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI. Methods and analysis Hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) is a multicentre, international, parallel-group randomised controlled trial (RCT). Patients who suffer a hip fracture are randomly allocated to either accelerated medical assessment and surgical repair with a goal of surgery within 6 hours of diagnosis or standard care where a repair typically occurs 24 to 48 hours after diagnosis. The primary outcome of this substudy is the development of AKI within 7 days of randomisation. We anticipate at least 1998 patients will participate in this substudy. Ethics and dissemination We obtained ethics approval for additional serum creatinine recordings in consecutive patients enrolled at 70 participating centres. All patients provide consent before randomisation. We anticipate reporting substudy results by 2021. Trial registration number NCT02027896; Pre-results.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Accelerated surgery ; Acute kidney injury ; Hip fracture
Publicat a:	BMJ open, Vol. 9 Núm. 9 (january 2019) , p. e033150, ISSN 2044-6055

DOI: 10.1136/bmjopen-2019-033150
PMID: 31551393

6 p, 356.0 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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