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Pàgina inicial > Articles > Articles publicats > Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection |
Data: | 2019 |
Resum: | Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation. |
Ajuts: | Ministerio de Economía y Competitividad MTM2015-64465-C2-1-R Agència de Gestió d'Ajuts Universitaris i de Recerca FI-B00184 Instituto de Salud Carlos III RD16-0025-0041 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Adult ; Archaea ; Bacteroides ; Butyrates ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes ; Cross-Sectional Studies ; Dysbiosis ; Feces ; Female ; Gastrointestinal Microbiome ; HIV Infections ; HIV-1 ; Humans ; Intestinal Mucosa ; Male ; Middle Aged ; Prognosis |
Publicat a: | Mucosal Immunology, Vol. 12 Núm. 1 (january 2019) , p. 232-246, ISSN 1935-3456 |
15 p, 3.9 MB |