The Drosophila melanogaster Genetic Reference Panel
MacKay, Trudy F. C. (Department of Genetics. North Carolina State University)
Richards, Stephen (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Stone, Eric A. (Department of Genetics. North Carolina State University)
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Ayroles, Julien F. (Harvard University)
Zhu, Dianhui (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Casillas Viladerrams, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Han, Yi (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Magwire, Michael M. (Department of Genetics. North Carolina State University)
Cridland, Julie M. (Department of Ecology and Evolutionary Biology. University of California-Irvine)
Richardson, Mark F. (Faculty of Life Sciences. University of Manchester)
Anholt, Robert R. H. (Department of Biology. North Carolina State University)
Barrón Aduriz, Maite Garazi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Bess, Crystal (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Blankenburg, Kerstin Petra (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Carbone, Mary Anna (Department of Genetics. North Carolina State University)
Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chaboub, Lesley (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Duncan, Laura (Department of Genetics. North Carolina State University)
Harris, Zeke (Department of Genetics. North Carolina State University)
Javaid, Mehwish (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Jayaseelan, Joy Christina (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Jhangiani, Shalini N. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Jordan, Katherine W. (Department of Genetics. North Carolina State University)
Lara, Fremiet (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Lawrence, Faye (Department of Genetics. North Carolina State University)
Lee, Sandra L. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Librado, Pablo (Universitat de Barcelona. Departament de Genètica)
Linheiro, Raquel S. (Faculty of Life Sciences. University of Manchester)
Lyman, Richard F. (Department of Genetics. North Carolina State University)
MacKey, Aaron J. (Center for Public Health Genomics. University of Virginia)
Munidasa, Mala (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Muzny, Donna Marie (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Nazareth, Lynne (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Newsham, Irene (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Perales, Lora (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Pu, Ling-Ling (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Qu, Carson (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Ràmia Jesús, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Reid, Jeffrey G. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Rollmann, Stephanie M. (Department of Biological Sciences. University of Cincinnati)
Rozas, Julio (Universitat de Barcelona. Departament de Genètica)
Saada, Nehad (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Turlapati, Lavanya (Department of Genetics. North Carolina State University)
Worley, Kim C. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Wu, Yuan-Qing (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Yamamoto, Akihiko (Department of Genetics. North Carolina State University)
Zhu, Yiming (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Bergman, Casey M. (Faculty of Life Sciences. University of Manchester)
Thornton, Kevin R. (Department of Ecology and Evolutionary Biology. University of California-Irvine)
Mittelman, David (Virginia Bioinformatics Institute. Department of Biological Sciences. Virginia Tech)
Gibbs, Richard A. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)

Data:	2012
Resum:	A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.
Ajuts:	Ministerio de Economía y Competitividad BFU 2009-09504
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Drosophila ; Genetic variation ; Genome-wide association studies ; Genomics
Publicat a:	Nature, Vol. 482, issue 7384 (Feb. 2012) , p. 173-178, ISSN 1476-4687

DOI: 10.1038/nature10811
PMID: 22318601

6 p, 807.2 KB

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