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Pàgina inicial > Articles > Articles publicats > CXCR4+-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis |
Data: | 2016 |
Resum: | Aim: Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equivalent material produced in E. coli. Results: Protein nanoparticles have been efficiently produced in L. lactis, showing the desired size, internalization properties and biodistribution. Conclusion: In vitro and in vivo data confirm the potential and robustness of the production platform, pointing out L. lactis as a fascinating cell factory for the biofabrication of protein materials intended for therapeutic applications. |
Ajuts: | Ministerio de Economía y Competitividad BIO2013-41019-P Instituto de Salud Carlos III PI15/00272 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-132 |
Nota: | Altres ajuts: CIBER de Bioingeniería, Biomateriales y Nanomedicina (project NANOPROTHER). A Villaverde received an ICREA ACADEMIA award. OC Garrido received a PhD fellowship from MECD and EGF a postdoctoral fellowship from INIA (DOC-INIA, INIA, MINECO). Unzueta received a Sara Borrell postdoctoral fellowship from ISCIII. |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Protein nanoparticles ; Recombinant proteins ; Tumor-homing peptides |
Publicat a: | Nanomedicine, Vol. 11, issue 18 (2016) , p. 2387-2398, ISSN 1748-6963 |
12 p, 5.9 MB |