The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement : evidence from routinely collected data
Burn, Edward (Nuffield University of Oxford. Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences)
Edwards, Christopher J. (University Hospital Southampton NHS Foundation Trust (Regne Unit))
Murray, David W. (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK)
Silman, Alan (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK)
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, UK)
Arden, N. K (MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, UK)
Pinedo-Villanueva, Rafael (MRC Lifecourse Epidemiology Unit, Southampton University (Southampton, Regne Unit))
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona)

Data:	2019
Resum:	To compare outcomes of total knee replacement (TKR) and total hip replacement (THR) for individuals with RA and OA. We performed a cohort study using routinely collected data. Oxford Knee Score, Oxford Hip Score, and EuroQol 5-dimension 3-level (EQ-5D-3L) questionnaires were collected before and 6 months after surgery. Multivariable regressions were used to estimate the association between diagnosis and post-operative scores after controlling for pre-operative scores and patient characteristics. Study cohorts included 2070 OA and 142 RA patients for TKR and 2030 OA and 98 RA patients for THR. Following TKR, the median Oxford Knee Score was 37 [interquartile range (IQR) 29-43] for OA and 36 (27-42) for RA while the median EQ-5D-3L was 0. 76 (0. 69-1. 00) and 0. 69 (0. 52-0. 85), respectively. After THR, the Oxford Hip Score was 42 (IQR 36-46) for OA and 39 (30-44) for RA while the EQ-5D-3L was 0. 85 (0. 69-1. 00) and 0. 69 (0. 52-1. 00), respectively. The estimated effect of RA, relative to OA, on post-operative scores was -0. 05 (95% CI -1. 57, 1. 48) for the Oxford Knee Score, -0. 09 (-0. 13, -0. 06) for the EQ-5D-3L following TKR, -1. 35 (-2. 93, -0. 22) for the Oxford Hip Score, and -0. 08 (-0. 12, -0. 03) for the EQ-5D-3L following THR. TKR and THR led to substantial improvements in joint-specific scores and overall quality of life. While diagnosis had no clinically meaningful effect on joint-specific outcomes, improvements in general quality of life were somewhat less for those with RA, which is likely due to the systemic and multijoint nature of rheumatoid disease.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Rheumatoid arthritis ; Osteoarthritis ; Outcome measures ; Quality of life ; Surgery
Publicat a:	Rheumatology, Vol. 58 (january 2019) , p. 1016-1024, ISSN 1462-0332

DOI: 10.1093/rheumatology/key409
PMID: 30608608

9 p, 289.6 KB

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