Skin Autofluorescence Measurement in Subclinical Atheromatous Disease : Results from the ILERVAS Project
Sánchez, Enric (Hospital Arnau de Vilanova (Lleida, Catalunya))
Betriu, Àngels (Hospital Arnau de Vilanova (Lleida, Catalunya))
Yeramian, Andree (Hospital Arnau de Vilanova (Lleida, Catalunya))
Fernández, Elvira (Hospital Arnau de Vilanova (Lleida, Catalunya))
Purroy, Francesc (Hospital Arnau de Vilanova (Lleida, Catalunya))
Sánchez-de-la-Torre, Manuel (Hospital Arnau de Vilanova (Lleida, Catalunya))
Pamplona, Reinald (Universitat de Lleida)
Miquel, Eva (Institut Català de la Salut. Centre d'Atenció Primària Borges Blanques (Lleida, Catalunya))
Kerkeni, Mohsen (University of Monastir)
Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lecube, Albert (Hospital Arnau de Vilanova (Lleida, Catalunya))
Hernández, Marta (Hospital Arnau de Vilanova (Lleida, Catalunya))
Rius, Ferran (Hospital Arnau de Vilanova (Lleida, Catalunya))
Polanco, Dinora (Hospital Arnau de Vilanova (Lleida, Catalunya))
Barbé, Ferran (Hospital Arnau de Vilanova (Lleida, Catalunya))
Torres, Gerard (Hospital Arnau de Vilanova (Lleida, Catalunya))
Suárez, Guillermo (Universitat de Lleida)
Portero-Otin, Manuel (Universitat de Lleida)
Jové, Mariona (Universitat de Lleida)
Colàs-Campàs, Laura (Hospital Arnau de Vilanova (Lleida, Catalunya))
Benabdelhak, Ikram (Hospital Arnau de Vilanova (Lleida, Catalunya))
Farràs, Cristina (Institut Català de la Salut. Centre d'Atenció Primària Borges Blanques (Lleida, Catalunya))
Ortega, Marta (Institut Català de la Salut. Centre d'Atenció Primària Borges Blanques (Lleida, Catalunya))
Valdivielso, José Manuel (Hospital Arnau de Vilanova (Lleida, Catalunya))
Bermúdez-López, Marcelino (Hospital Arnau de Vilanova (Lleida, Catalunya))
Martínez-Alonso, Montse (Hospital Arnau de Vilanova (Lleida, Catalunya))
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Aim: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk. Methods: A cross-sectional study in which 2,568 non-diabetic subjects of both sexes without cardiovascular disease were included. Subcutaneous content of AGEs was assessed by skin autofluorescence (SAF) and subclinical atheromatous disease was measured by assessing the atheromatous plaque burden in carotid and femoral regions using ultrasonography. In addition, serum pentosidine, carboxymethyl-lysine (CML) and AGE receptors (RAGE) were assessed in a nested case-control study with 41 subjects without plaque and 41 individuals subjects with generalized disease. Results: Patients with atheromatous plaque had a higher SAF than those with no plaque (1. 9 [1. 7 to 2. 3] vs. 1. 8 [1. 6 to 2. 1] arbitrary units (AU), p % 0. 001). The SAF correlated with the total number of affected regions (r = 0. 171, p < 0. 001), increasing progressively from 1. 8 [1. 6 to 2. 1] AU in those without atheromatous disease to 2. 3 [1. 9 to 2. 7] AU in patients with ≥ 8 plaques (p < 0. 001). A correlation was also observed between SAF and the total plaque area (r = 0. 113, p < 0. 001). The area under the Receiver Operating Characteristic curve was 0. 65 (0. 61 to 0. 68) for identifying male subjects with atheromatous disease. The multivariable logistic regression model showed a significant and independent association between SAF and the presence of atheromatous disease. However, no significant differences in serum pentosidine, CML, and RAGE were observed. Conclusions: Increased subcutaneous content of AGEs is associated with augmented atheromatous plaque burden. Our results suggest that SAF may provide clinically relevant information to the current strategies for the evaluation of cardiovascular risk, especially among the male population.
Ajuts:	Instituto de Salud Carlos III II14//00008
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra, i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Advanced glycation end-products ; Atheromatous plaque burden ; Cardiovascular risk ; Skin autofluorescence
Publicat a:	Journal of Atherosclerosis and Thrombosis, Vol. 26 (october 2019) , p. 879-889, ISSN 1880-3873

DOI: 10.5551/jat.47498
PMID: 30842389

12 p, 182.8 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats