Poor outcome in hypoxic endometrial carcinoma is related to vascular density
Reijnen, Casper (Radboud University Medical Center)
van Weelden, Willem Jan (Radboud University Medical Center)
Arts, Martijn S. J. P. (Radboud University Medical Center)
Peters, Johan P. (Radboud University Medical Center)
Rijken, Paul F. (Radboud University Medical Center)
van de Vijver, Koen (Universitair Ziekenhuis Gent)
Santacana, Maria (Hospital Arnau de Vilanova (Lleida, Catalunya))
Bronsert, Peter (Universitätsklinikum Freiburg)
Bulten, Johan (Radboud University Medical Center)
Hirschfeld, Marc (Universitätsklinikum Freiburg)
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya))
Krakstad, Camilla (Haukeland universitetssjukehus)
Trovik, Jone (Haukeland universitetssjukehus)
Haldorsen, Ingfrid S. (Universitetet i Bergen)
Huvila, Jutta (Turun Yliopisto)
Koskas, Martin (Hôpital Bichat - Claude-Bernard)
Weinberger, Vit (Masarykova univerzita)
Minar, Lubos (Masarykova univerzita)
Jandakova, Eva (Masarykova univerzita)
Snijders, Marc P. L. M. (Canisius Wilhelmina Ziekenhuis)
van den Berg-van Erp, Saskia (Canisius Wilhelmina Ziekenhuis)
Küsters-Vandevelde, Heidi V. N. (Canisius Wilhelmina Ziekenhuis)
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya))
Amant, Frederic (Katholieke Universiteit Leuven)
Massuger, Leon F. A. G. (Radboud University Medical Center)
Bussink, Johan (Radboud University Medical Center)
Pijnenborg, Johanna M. A. (Radboud University Medical Center)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. Sixty-three (16. 4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0. 002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3. 71, p = 0. 002), DDFS (HR 2. 68, p = 0. 009) and a trend for reduced DFS (HR 1. 87, p = 0. 054). This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Prognostic markers ; Endometrial cancer
Publicat a:	British Journal of Cancer, Vol. 120 (april 2019) , p. 1037-1044, ISSN 1532-1827

DOI: 10.1038/s41416-019-0461-2
PMID: 31011231

8 p, 6.1 MB

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