Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia
Zapata-Arriaza, Elena (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Mancha, Fernando (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Moniche, Francisco (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Pardo-Galiana, Blanca (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Serrano-Gotarredona, Pilar (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Navarro-Herrero, Silvia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Pallisa, Esther (Hospital Universitari Vall d'Hebron)
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vega-Salvatierra, Ángela (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Escudero-Martínez, Irene (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ramos-Herrero, Víctor Darío (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Azurmendi, Leire (University of Geneva)
Charles Sanchez, Jean (University of Geneva)
Montaner, Joan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Universitat Autònoma de Barcelona

Data:	2019
Resum:	To confirm the diagnostic accuracy of candidate biomarkers in stroke-associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0. 04) and both suPAR and SAA at 48 h (P = 0. 036 and P = 0. 057) were associated with pneumonia. The combination of SAA > 25. 15 mg/dL and suPAR> 3. 14 ng/mL at 48 h had 80% sensitivity and 95. 8% specificity when both biomarkers were above the cut-off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies.
Ajuts:	Instituto de Salud Carlos III PI14/00971 Instituto de Salud Carlos III JR16/000
Nota:	Funding Information This project was partially funded by the ISCIII project PI14/00971. The ITRIBiS project (Improving Translational Research Potential at the Institute of Biomedicine of Seville) has the registration number REGPOT-2013-1. Cooperative Cerebrovascular Disease Research Network (INVICTUS+) (RD16/0019/0015). AB is supported by a Juan Rodes research contract (JR16/0008) from Instituto de Salud Carlos III. To the Pneumonia in Stroke Consensus (PISCES) Group and specially to Craig Smith and Andreas Meisel for interesting conversations on the use of chest CT and other biomarkers for the diagnosis of post stroke pneumonia.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adrenomedullin ; Aged ; Aged, 80 and over ; Biomarkers ; Early Diagnosis ; Female ; Humans ; Male ; Peptide Fragments ; Pneumonia ; Prognosis ; Protein Precursors ; Receptors, Urokinase Plasminogen Activator ; Serum Amyloid A Protein ; Stroke
Publicat a:	Annals of Clinical and Translational Neurology, Vol. 6 (july 2019) , p. 1882-1887, ISSN 2328-9503

DOI: 10.1002/acn3.50849
PMID: 31365180

6 p, 297.0 KB

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