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| Pàgina inicial > Articles > Articles publicats > Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke : |
(Instituto de Investigación Sanitaria de Santiago (IDIS)) (Instituto de Investigación Sanitaria de Santiago (IDIS)) (Instituto de Investigación Sanitaria de Santiago (IDIS)) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Institut d'Investigació Biomèdica Sant Pau) (Complejo Hospitalario Universitario de A Coruña) (Hospital Universitari de Girona Doctor Josep Trueta)| Data: | 2019 |
| Resum: | The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62. 1%; mean age, 68. 2 ± 11. 4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] ≤ 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 ± 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1α were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1α serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0. 01). High serum levels at day 7 of VEGF (OR, 19. 3), Ang-1 (OR, 14. 7), G-CSF (OR, 9. 6), and SDF-1α (OR, 28. 5) were independently associated with good outcome at 12 months (all p < 0. 0001). On the other hand, serum levels of VEGF (B, - 21. 4), G-CSF (B, - 14. 0), Ang-1 (B, - 13. 3), and SDF-1α (B, - 44. 6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0. 01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1α at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up. |
| Ajuts: | Ministerio de Economía y Competitividad SAF2014-56336-R Agencia Estatal de Investigación RTI2018-102165-B-I00 Agencia Estatal de Investigación SAF2017-84267-R Instituto de Salud Carlos III PI13-00292 Instituto de Salud Carlos III PI14-01879 Instituto de Salud Carlos III PI17-01103 Instituto de Salud Carlos III CP12-03121 Instituto de Salud Carlos III CPII17-00027 Instituto de Salud Carlos III CP14-00154 Instituto de Salud Carlos III CPII19-00020 |
| Nota: | Altres ajuts: This project was partially supported by grants from Xunta de Galicia (Consellería Educación: GRC2014/027 and IN607A2018/3), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS (RD16/0019), and by the European Union FEDER program. |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Growth factors ; Infarct volume ; Ischemic stroke ; Prognosis |
| Publicat a: | Translational Stroke Research, Vol. 11 (november 2019) , p. 653-663, ISSN 1868-601X |
