Phase 1 study of capmatinib in MET-positive solid tumor patients : Dose escalation and expansion of selected cohorts
Bang, Yung-Jue (Seoul National University College of Medicine)
Su, Wu-Chou (National Cheng Kung University Hospital)
Schuler, Martin (University Duisburg-Essen and German Cancer Consortium (DKTK))
Nam, Do-Hyun (Samsung Medical Center)
Lim, Wan Teck (National Cancer Centre)
Bauer, Todd M. (PLLC)
Azaro, Analía (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Poon, Ronnie Tung Ping (Queen Mary Hospital)
Hong, David (University of Texas/MD Anderson Cancer Center)
Lin, Chia-Chi (National Taiwan University Hospital (Taipei, Taiwan))
Akimov, Mikhail (Novartis Pharma AG)
Ghebremariam, Samson (Novartis Pharmaceuticals Corporation)
Zhao, Sylvia (China Novartis Institutes for Biomedical Research)
Giovannini, Monica (Novartis Pharmaceuticals Corporation)
Ma, Brigette (The Chinese University of Hong Kong)

Data:	2019
Resum:	Capmatinib is an oral, ATP-competitive, and highly potent, type 1b MET inhibitor. Herein, we report phase 1 dose-escalation results for capmatinib in advanced MET-positive solid tumor patients and dose expansion in advanced non-lung tumors. Capmatinib was well tolerated with a manageable safety profile across all explored doses. Dose-limiting toxicities (DLT) occurred at 200 mg twice daily (bid), 250 mg bid, and 450 mg bid capsules; however, no DLT were reported at 600 mg bid (capsules). Capmatinib tablets at 400 mg bid had comparable tolerability and exposure to that of 600 mg bid capsules. Maximum tolerated dose was not reached; recommended phase 2 dose was 400 mg bid tablets/600 mg bid capsules; at this dose, C >EC (90% inhibition of c-MET phosphorylation in animal models) is expected to be achieved and maintained. Among the dose-expansion patients (N = 38), best overall response across all cohorts was stable disease (gastric cancer 22%, hepatocellular carcinoma 46%, other indications 28%); two other indication patients with gene copy number (GCN) ≥6 achieved substantial tumor reduction. Near-complete immunohistochemically determined phospho-MET inhibition (H-score = 2) was shown following capmatinib 450 mg bid capsule in paired biopsies obtained from one advanced colorectal cancer patient. Incidence of high-level MET GCN (GCN ≥6) and MET-overexpressing (immunohistochemistry 3+) tumors in the expansion cohorts was 8% and 13%, respectively; no MET mutations were observed. Thus, the recommended phase 2 dose (RP2D) of capmatinib was 600 mg bid capsule/400 mg bid tablet. Capmatinib was well tolerated and showed antitumor activity and acceptable safety profile at the RP2D. (ClinicalTrials. gov Identifier: NCT01324479). MET dysregulation is an important newly established molecular driver of tumorigenesis in various cancers and is recognized as a negative prognostic factor. The findings of this study provide the recommended phase 2 dose (RP2D) of capmatinib and also safety and efficacy data in selected expansion cohorts treated at the RP2D.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Capmatinib ; MET amplification ; MET dysregulation ; Phase 1 ; Solid tumors
Publicat a:	Cancer Science, Vol. 111 (december 2019) , p. 536-547, ISSN 1349-7006

DOI: 10.1111/cas.14254
PMID: 31778267

12 p, 435.5 KB

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