|
|
|||||||||||||||
|
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español | |||||||||
| Pàgina inicial > Articles > Articles publicats > Brain imaging correlates of self- and other-reflection in schizophrenia |
| Data: | 2019 |
| Resum: | An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results. Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing. Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity. Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group. |
| Ajuts: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-01271 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1265 Ministerio de Economía y Competitividad FJCI-2015-25278 Ministerio de Economía y Competitividad FFI2016-77647-C2-2-P Instituto de Salud Carlos III CPII16-00018 Instituto de Salud Carlos III CM15-00024 Instituto de Salud Carlos III PI14-01151 Instituto de Salud Carlos III PI18-00810 Instituto de Salud Carlos III PI18-00877 Instituto de Salud Carlos III PI18/00880 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Psychosis ; Schizophrenia ; Self-reflection ; Other-reflection ; Fmri ; Temporo-parietal junction |
| Publicat a: | NeuroImage. Clinical, Vol. 25 (december 2019) , ISSN 2213-1582 |
9 p, 1.6 MB |