Sexual Dimorphism in the Behavioral Responses and the Immunoendocrine Status in d-Galactose-Induced Aging
Baeta Corral, Raquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Castro-Fuentes, Rafael (University of La Laguna. Department of Basic Medical Sciences)
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)

Data:	2018
Resum:	For almost 20 years, chronic systemic d-galactose, a monosaccharide abundantly present in milk products, fruits, and vegetables, has been used as a tool to achieve models of accelerated aging. Its neurotoxicity, induced by abnormal accumulation of reactive oxygen species and advanced glycation end products, has been widely reported. However, behavioral outcomes are still controversial and little is known about sex-dependent vulnerability. We performed a comprehensive behavioral and multifunctional screening of the chronic effects of low (50 mg/kg) and high (100 mg/kg) doses of d-galactose in 6-month-old male and female gold-standard C57BL/6 mice. Twelve classical tests with convergent validity analyzed sensorimotor, emotional and cognitive domains, indicating the existence of thresholds of response. Distinct vulnerability patterns were found in a selective sex- and dose-dependent manner. In males, d-galactose induced sensorimotor impairment and immunoendocrine senescence, but the low dose resulted in improved learning and memory. Oppositely, d-galactose-treated females exhibited a dose-dependent worse motor and spatial learning, but improved memory. Behavioral outcome items point at distinct neuronal substrates underlying the functional capacity of d-galactose-treated animals to meet task-dependent performance demands. They support that males and females can be regarded as two exceptional natural scenarios to study the functional interplay in the cross talk of homeostatic networks in aging.
Ajuts:	European Commission 737390 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1354 Instituto de Salud Carlos III AES-PI10/00283
Nota:	Altres ajuts: R.B.C. received a predoctoral grant FI-DGR (2012FI_B1 00198) from Secretaria d' Universitat i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Animal model ; Behavioral screening ; Functional screening ; Frailty ; Corticosterone ; Thymus
Publicat a:	The journals of gerontology, Vol. 73 Núm. 9 (february 2018) , p. 1147-1157, ISSN 1758-535X

DOI: 10.1093/gerona/gly031
PMID: 29471511

11 p, 5.8 MB

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