Aggressive multiple sclerosis (2) : Treatment
Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Iacobaeus, Ellen
Amato, Maria Pia
Derfuss, Tobias
Vukusic, Sandra
Hemmer, Bernhard
Brundin, Lou
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.
Note:	Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The workshop on which the manuscript is based was supported in its entirety by the European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Aggressive ; Highly active ; Multiple sclerosis ; Disability ; Relapsing-remitting ; Treatment response
Published in:	Multiple sclerosis, Vol. 26 (june 2020) , p. 1045-1063, ISSN 1477-0970

DOI: 10.1177/1352458520924595
PMID: 32530366

19 p, 669.3 KB

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