Effect of protocol-related variables and women's characteristics on the cumulative false-positive risk in breast cancer screening
Román, R. (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
Sala, Maria (Institut Municipal d'Investigació Mèdica (Barcelona, Catalunya))
Salas, D. (Centre Superior d'Investigació en Salut Pública, València)
Ascunce, Nieves (Instituto de Salud Pública de Navarra)
Zubizarreta Alberdi, Raquel (Conselleria de Sanidade de la Xunta de Galicia)
Castells, Xavier (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)

Data:	2011
Resum:	Background: Reducing the false-positive risk in breast cancer screening is important. We examined how the screening-protocol and women's characteristics affect the cumulative false-positive risk. Methods: This is a retrospective cohort study of 1 565 364 women aged 45-69 years who underwent 4 739 498 screening mammograms from 1990 to 2006. Multilevel discrete hazard models were used to estimate the cumulative false-positive risk over 10 sequential mammograms under different risk scenarios. Results: The factors affecting the false-positive risk for any procedure and for invasive procedures were double mammogram reading [odds ratio (OR) = 2. 06 and 4. 44, respectively], two mammographic views (OR = 0. 77 and 1. 56, respectively), digital mammography (OR = 0. 83 for invasive procedures), premenopausal status (OR = 1. 31 and 1. 22, respectively), use of hormone replacement therapy (OR = 1. 03 and 0. 84, respectively), previous invasive procedures (OR = 1. 52 and 2. 00, respectively), and a familial history of breast cancer (OR = 1. 18 and 1. 21, respectively). The cumulative false-positive risk for women who started screening at age 50-51 was 20. 39% [95% confidence interval (CI) 20. 02-20. 76], ranging from 51. 43% to 7. 47% in the highest and lowest risk profiles, respectively. The cumulative risk for invasive procedures was 1. 76% (95% CI 1. 66-1. 87), ranging from 12. 02% to 1. 58%. Conclusions: The cumulative false-positive risk varied widely depending on the factors studied. These findings are relevant to provide women with accurate information and to improve the effectiveness of screening programs.
Ajuts:	Instituto de Salud Carlos III PI061230
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Breast cancer ; False positive ; Invasive procedures ; Risk factors ; Screening ; Variability
Publicat a:	Annals of oncology, Vol. 23 (march 2011) , p. 104-111, ISSN 1569-8041

DOI: 10.1093/annonc/mdr032
PMID: 21430183

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