Boosting cancer immunotherapies with optical biosensor nanotechnologies
Soler Aznar, Maria (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)

Data:	2019
Resum:	An increasing number of cancer patients have found new hope in the form of recently discovered cell immunotherapies. These novel treatments empower our own immune system to fight and eradicate the malignant tumours, even in metastatic stages. Unprecedented outcomes have been demonstrated with bioengineered cells especially modified in laboratories to trigger a highly specific and active anti-tumour function; however, a main bottleneck for the implementation of these promising therapies resides in the old-fashioned and limited techniques employed for the in vitroanalysis and study of cells during manufacturing and testing processes. Optical label-free biosensors are currently arising as promising analytical technologies for a simplified and accurate cell analysis. In particular, biosensors based on evanescent field principles enable direct, non-invasive, and real-time monitoring of biological events, showing outstanding sensitivities and excellent robustness. Furthermore, these biosensors are easily incorporated in lab-on-a-chip platforms for simple operation and implementation in clinical laboratories. In this review, the authors present and discuss the more recent research aimed to develop label-free optical biosensors for the analysis of live cells and the direct benefits offered to cell immunotherapy production allowing for its widespread implementation.
Ajuts:	Agencia Estatal de Investigación TEC2016-78515-R Agencia Estatal de Investigación SEV-2017-0706
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adoptive cell transfer ; Biomedical engineering ; Biosensors ; Cancer ; Cell analysis ; Immunotherapy ; Nanoplasmonics
Publicat a:	European Medical Journal Oncology, Vol. 4, Núm. 4 (December 2019) , p. 124-132, ISSN 2054-619X

Adreça alternativa: https://www.emjreviews.com/oncology/article/boosting-cancer-immunotherapies-with-optical-biosensor-nanotechnologies/

9 p, 2.2 MB

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