Understanding the relevance of DNA methylation changes in immune differentiation and disease
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Immune cells are one of the most complex and diverse systems in the human organism. Such diversity implies an intricate network of different cell types and interactions that are dependently interconnected. The processes by which different cell types differentiate from progenitors, mature, and finally exert their function requires an orchestrated succession of molecular processes that determine cell phenotype and function. The acquisition of these phenotypes is highly dependent on the establishment of unique epigenetic profiles that confer identity and function on the various types of effector cells. These epigenetic mechanisms integrate microenvironmental cues into the genome to establish specific transcriptional programs. Epigenetic modifications bridge environment and genome regulation and play a role in human diseases by their ability to modulate physiological programs through external stimuli. DNA methylation is one of the most ubiquitous, stable, and widely studied epigenetic modifications. Recent technological advances have facilitated the generation of a vast amount of genome-wide DNA methylation data, providing profound insights into the roles of DNA methylation in health and disease. This review considers the relevance of DNA methylation to immune system cellular development and function, as well as the participation of DNA methylation defects in immune-mediated pathologies, illustrated by selected paradigmatic diseases.
Ajuts:	Ministerio de Economía y Competitividad SAF2014-55942-R Agencia Estatal de Investigación SAF2017-88086-R
Nota:	Altres ajuts: We thank CERCA Programme/Generalitat de Catalunya and Josep Carreras Foundation for institutional support. E.B. was funded by [...] and was co-funded by FEDER funds/European Regional Development Fund (ERDF)-a way to build Europe.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Matèria:	B cells ; DNA methylation ; Familial Mediterranean Fever ; NK cells ; T cells ; Cryopyrin-associated periodic fever syndrome ; Epigenetics ; Granulocytes ; Immune system ; Innate immune deficiencies ; Innate lymphoid cells ; Monocytes ; Primary immunodeficiencies ; Rheumatoid arthritis ; Systemic lupus erythematosus
Publicat a:	Genes, Vol. 11 Núm. 1 (january 2020) , p. 110, ISSN 2073-4425

DOI: 10.3390/genes11010110
PMID: 31963661

25 p, 1.3 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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