Size-controlled synthesis of Sub-10-nanometer citrate-stabilized gold nanoparticles and related optical properties
Piella, Jordi (Institut Català de Nanociència i Nanotecnologia)
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Data:	2016
Resum:	Highly monodisperse, biocompatible and functionalizable sub-10-nm citrate-stabilized gold nanoparticles (Au NPs) have been synthesized following a kinetically controlled seeded-growth strategy. The use of traces of tannic acid together with an excess of sodium citrate during nucleation is fundamental in the formation of a high number (7 × 10 NPs/mL) of small ∼3. 5 nm Au seeds with a very narrow distribution. A homogeneous nanometric growth of these seeds is then achieved by adjusting the reaction parameters: pH, temperature, sodium citrate concentration and gold precursor to seed ratio. We use this method to produce Au NPs with a precise control over their sizes between 3. 5 and 10 nm and a versatile surface chemistry allowing studying the size-dependent optical properties in this transition size regime lying between clusters and nanoparticles. Interestingly, an inflection point is observed for Au NPs smaller than 8 nm in which the sensitivity of the localized surface plasmon resonance (LSPR) peak position as a function of NPs size and surface modifications dramatically increase. These studies are relevant in the design of the final selectivity, activity and compatibility of Au NPs, especially in those (bio)applications where size is a critical parameter (e. g. , biodistribution, multiplex labeling, and protein interaction).
Ajuts:	European Commission 262163 European Commission 322153 European Commission 604602 Ministerio de Ciencia e Innovación MAT2012-33330 Ministerio de Economía y Competitividad RYC-2012-10991 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-612
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Gold Nanoparticles ; Kinetically controlled ; Localized surface plasmon resonance ; Narrow distribution ; Protein interaction ; Reaction parameters ; Size controlled synthesis ; Size-dependent optical properties
Publicat a:	Chemistry of materials, Vol. 28, issue 4 (2016) , p. 1066-1075, ISSN 1520-5002

DOI: 10.1021/acs.chemmater.5b04406

Postprint 25 p, 2.3 MB

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